Evidence map›Paper›PMID 30329033›Full record

Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2019

Using the Multidimensional Prognostic Index to Predict Clinical Outcomes of Hospitalized Older Persons: A Prospective, Multicenter, International Study.

Alberto Pilotto, Nicola Veronese, Julia Daragjati, Alfonso J Cruz-Jentoft, Maria Cristina Polidori, Francesco Mattace-Raso, Marc Paccalin, Eva Topinkova, Giacomo Siri, Antonio Greco and 4 more

Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 8 countries.

Alberto PilottoDepartment of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. Galliera Hospital, National Relevance and High Specialization Hospital, Genoa, Italy.
Nicola VeroneseDepartment of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. Galliera Hospital, National Relevance and High Specialization Hospital, Genoa, Italy.
Julia DaragjatiGeriatrics Unit, San Antonio Hospital, Padua, Italy.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Maria Cristina PolidoriDepartment of Medicine II, University of Cologne Medical Faculty, Germany.
Francesco Mattace-RasoDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Marc PaccalinGeriatrics Department, Poitiers University Hospital, France.
Eva TopinkovaDepartment of Geriatrics, First Faculty of Medicine, Charles University in Prague, Czech Republic.
Giacomo SiriDepartment of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. Galliera Hospital, National Relevance and High Specialization Hospital, Genoa, Italy.
Antonio GrecoGeriatrics Unit, IRCCS CSS, San Giovanni Rotondo, Italy.
Arduino A MangoniDepartment of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Adelaide, Australia.
Stefania MaggiAging Section, National Research Council, Padova, Italy.
Luigi FerrucciNational Institute on Aging, Baltimore, Maryland.
MPI_AGE Investigators
Ente Ospedaliero Ospedali Galliera · ITCharles University · CZErasmus MC · NLFlinders University · AUInstituto Ramón y Cajal de Investigación Sanitaria · ESIstituti di Ricovero e Cura a Carattere Scientifico · ITNational Institute on Aging · USNational Research Council · ITOspedale Sant Antonio · ITUniversité de Poitiers · FRUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultidimensional Prognostic Index (MPI) is useful as a prognostic tool in hospitalized older patients, but our knowledge is derived from retrospective studies. We therefore aimed to evaluate in a multicenter, longitudinal, cohort study whether the MPI at hospital admission is useful to identify groups with different mortality risk and whether MPI at discharge may predict institutionalization, rehospitalization, and use of home care services during 12 months.

methodsThis longitudinal study, carried out between February 2015 and August 2017, included nine public hospitals in Europe and Australia. A standardized comprehensive geriatric assessment including information on functional, nutritional, cognitive status, risk of pressure sores, comorbidities, medications, and cohabitation status was used to calculate the MPI and to categorize participants in low, moderate, and severe risk of mortality. Data regarding mortality, institutionalization, rehospitalization, and use of home care services were recorded through administrative information.

resultsAltogether, 1,140 hospitalized patients (mean age 84.1 years, women = 60.8%) were included. In the multivariable analysis, compared to patients with low risk group at admission, patients in moderate (odds ratio [OR] = 3.32; 95% CI: 1.79-6.17; p < .001) and severe risk (OR = 10.72, 95% CI: 5.70-20.18, p < .0001) groups were at higher risk of overall mortality. Among the 984 older patients with follow-up data available, those in the severe-risk group experienced a higher risk of overall mortality, institutionalization, rehospitalization, and access to home care services.

conclusionsIn this cohort of hospitalized older adults, higher MPI values are associated with higher mortality and other negative outcomes. Multidimensional assessment of older people admitted to hospital may facilitate appropriate clinical and postdischarge management.

Indexed as

Geriatric AssessmentHospitalizationAgedAged, 80 and overAustraliaEuropeFemaleHumansLongitudinal StudiesMalePredictive Value of TestsPrognosisProspective StudiesRisk AssessmentROC CurveAgedCohort studyHospitalMultidimensional Prognostic IndexPrognosis

Identifiers

PMID30329033
PMCPMC6940980
OpenAlexW2896805194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.