Evidence map›Paper›PMID 30329018›Full record

ArticleBiology of reproduction2019

Seminal plasma modulates expression of endometrial inflammatory meditators in the bovine†.

Laila A Ibrahim, Jason A Rizo, Pedro L P Fontes, G Cliff Lamb, John J Bromfield

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of reproduction, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 54 citations in OpenAlex.

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  6. The immunomodulatory role of seminal plasma in endometrial receptivity and embryo implantation.American journal of clinical and experimental immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laila A IbrahimDepartment of Animal Sciences, University of Florida, Gainesville, Florida, USA.
Jason A RizoDepartment of Animal Sciences, University of Florida, Gainesville, Florida, USA.
Pedro L P FontesDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
G Cliff LambDepartment of Animal Science, Texas A&M University, College Station, Texas, USA.
John J BromfieldDepartment of Animal Sciences, University of Florida, Gainesville, Florida, USA.
University of Florida · USTexas A&M University · US

Funding

Uterine infection and infertility: how microbial infection of the reproductive tract causes ovarian dysfunction.R01HD084316 · NICHD · UNIVERSITY OF FLORIDA · PI BROMFIELD, JOHN J · 2016 to 2020
$1.7M
NICHD NIH HHS R01 HD084316
6 · The paper itself

Abstract

Seminal plasma has conventionally been viewed as a transport and survival medium for mammalian sperm; however, its role now extends beyond this process to actively targeting female tissues. Studies in rodents, swine, and humans demonstrate that seminal plasma induces molecular and cellular changes within the endometrium or cervix following insemination. Seminal-plasma-induced alterations to the maternal environment have been theorized to facilitate embryo development, modulate maternal immunity toward the conceptus, and potentially improve pregnancy success. It is unknown if bovine seminal plasma modulates the uterine environment following insemination in the cow, where routine use of artificial insemination reduces maternal exposure to seminal plasma. We hypothesize that seminal plasma modulates the expression of inflammatory mediators in the endometrium, altering the maternal environment of early pregnancy. In vitro, seminal plasma altered intact endometrial explant expression of CSF2, IL1B, IL6, IL17A, TGFB1, IFNE, PTGS2, and AKR1C4. Furthermore, endometrial epithelial cell CSF2, CXCL8, TGFB1, PTGS2, and AKR1C4 expression were increased after seminal plasma exposure, while endometrial stromal cell CSF2, IL1B, IL6, CXCL8, IL17A, TGFB1, PTGS2, and AKR1C4 expression were increased following seminal plasma exposure. Endometrial expression of IL1B was increased in the cow 24 h after uterine infusion of seminal plasma, while other evaluated inflammatory mediators remained unchanged. These data indicate that seminal plasma may induce changes in the bovine endometrium in a temporal manner. Understanding the role of seminal plasma in modulating the maternal environment may aid in improving pregnancy success in cattle.

Indexed as

CattleGene Expression RegulationAnimalsEndometriumEpithelial CellsFemaleInflammationInsemination, ArtificialMaleSemenTime Factorsendometrial epitheliumendometrial stromaendometriuminflammationinseminationseminal plasma

Identifiers

PMID30329018
PMCPMC6437260
OpenAlexW2898014717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.