Evidence map›Paper›PMID 30328957›Full record

ReviewRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

Noninvasive brain stimulation in psychiatric disorders: a primer.

Andre R Brunoni, Bernardo Sampaio-Junior, Adriano H Moffa, Luana V Aparício, Pedro Gordon, Izio Klein, Rosa M Rios, Lais B Razza, Colleen Loo, Frank Padberg and 1 more

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04889976 (Psychological Interventions and Transcranial Direct Current Stimulation for the Treatment of Major Depressive Disorder), which is not on this map. Cited by 77 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 12 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04889976 nacompletednot on this map

Psychological Interventions and Transcranial Direct Current Stimulation for the Treatment of Major Depressive Disorder

TypeinterventionalSponsorUniversity of Sao PauloRan2021 to 2022Enrolled210ConditionsMajor Depressive Disorder, Unipolar DepressionArmsDouble Active: Active portable transcranial stimulation (ptES) and active internet-based behavioral therapy (iBT), ptES-only: Active portable transcranial stimulation (ptES) and sham internet-based behavioral therapy (iBT), Double-sham: Sham portable transcranial stimulation (ptES) and sham internet-based behavioral therapy (iBT)
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 12 syntheses or guidelines pooled it, 195 citations in OpenAlex.

  1. Pooled it
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  8. Digitalized transcranial electrical stimulation: A consensus statement.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Pooled it
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  10. Evidence-based umbrella review of cognitive effects of prefrontal tDCS.Social cognitive and affective neuroscience · 2022
    Pooled it
  11. Pooled it
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  13. Trial
  14. Cortical thickness is related to working memory performance after non-invasive brain stimulation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Trial
  15. Trial
  16. Treatment of mixed depression with theta-burst stimulation (TBS): results from a double-blind, randomized, sham-controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Trial
  17. Trial
  18. Distinct trajectories of response to prefrontal tDCS in major depression: results from a 3-arm randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
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  20. Trial

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Andre R BrunoniServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.ORCID 0000-0002-6310-3571
Bernardo Sampaio-JuniorServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Adriano H MoffaBlack Dog Institute, School of Psychiatry, University of New South Wales, Sydney, Australia.
Luana V AparícioServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Pedro GordonServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Izio KleinServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Rosa M RiosServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Lais B RazzaServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Colleen LooBlack Dog Institute, School of Psychiatry, University of New South Wales, Sydney, Australia.
Frank PadbergInstituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN), Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Leandro ValiengoServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Hospital Universitário da Universidade de São Paulo · BRBlack Dog Institute · AUUniversidade Brasil · BRLudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNoninvasive brain stimulation (NIBS) techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), are increasingly being used to treat mental disorders, particularly major depression. The aim of this comprehensive review is to summarize the main advances, limitations, and perspectives of the field.

methodsWe searched PubMed and other databases from inception to July 2017 for articles, particularly systematic reviews and meta-analyses, evaluating the use of NIBS in psychiatric disorders.

resultsWe reviewed the mechanisms of action, safety, tolerability, efficacy, and relevant clinical parameters of NIBS. Repetitive TMS is already an established technique for the treatment of depression, and there is theoretically room for further methodological development towards a high-end therapeutic intervention. In contrast, tDCS is a technically easier method and therefore potentially suitable for wider clinical use. However the evidence of its antidepressant efficacy is less sound, and a recent study found tDCS to be inferior to antidepressant pharmacotherapy. Clinical trials using rTMS for other mental disorders produced mixed findings, whereas tDCS use has not been sufficiently appraised.

conclusionThe most promising results of NIBS have been obtained for depression. These techniques excel in safety and tolerability, although their efficacy still warrants improvement.

Indexed as

Clinical Trials as TopicEvidence-Based MedicineHumansMental DisordersTranscranial Direct Current StimulationTranscranial Magnetic Stimulation

Identifiers

PMID30328957
PMCPMC6781710
OpenAlexW2897101520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.