ArticleJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Six-minute walk distance and survival time in patients with idiopathic pulmonary fibrosis in Brazil.
Article in Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Reflections of upper extremity performance in idiopathic pulmonary fibrosis on exercise capacity, clinical status, and quality of life.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2026Article
- Evaluation of screening methods for preclinical interstitial lung disease associated with rheumatoid arthritis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Article
- Factors influencing long-term outcomes in fibrotic interstitial lung disease (F-ILD) diagnosed through multidisciplinary discussion (MDD): a prospective cohort study.European journal of medical research · 2024Article
- Multidisciplinary-derived clinical score for accurate prediction of long-term mortality in fibrotic lung disease patients.European journal of medical research · 2024Article
- Clinical Characteristics of Individuals with Interstitial Lung Diseases and Indication of End-of-Life Care.Journal of clinical medicine · 2023Article
- Association of the 6-minute walking test ratio and difference with pulmonary function in patients with interstitial lung disease.Saudi medical journal · 2023Article
- Prognostic Value of Pace Variability, a Novel 6MWT-Derived Feature, in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Article
- The 6-min walk test as a primary end-point in interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Six-minute walk test and its predictability in outcome of COVID-19 patients.Journal of education and health promotion · 2022Article
- Mortality and survival in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.ERJ open research · 2022Review
- Six-minute walk test in patients with idiopathic pulmonary fibrosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
- Clinical implications of six-minute walk test in patients with idiopathic pulmonary fibrosis: a retrospective cohort study.Therapeutic advances in respiratory diseaseArticle
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Abstract
objectiveTo determine the cut-off point for the six-minute walk distance (6MWD) that indicates lower survival time in patients with idiopathic pulmonary fibrosis (IPF) in Brazil.
methodsThis was retrospective study carried out in two referral centers for IPF. The 6MWT was performed twice, considering the highest value of the 6MWD. Various cut-off points were estimated, in absolute values and in percentage of predicted values, using ROC curves, the Kaplan-Meier method, and data from other studies.
resultsThe sample comprised 70 patients with IPF. The mean age was 71.9 ± 6.4 years, and 50 patients (71.4%) were male. The mean FVC was 76.6 ± 18.2% of predicted value. The mean SpO2 at rest before and after 6MWT were 93.8 ± 2.5% and 85.3 ± 6.5%, respectively. The median survival time was 44 months (95% CI: 37-51 months). The mean 6MWD was 381 ± 115 m (79.2 ± 24.0% of predicted). After the analyses, the best cut-off points for estimating survival were 6MWD < 330 m and < 70% of predicted. The median survival time of patients with a 6MWD < 330 m was 24 months (95% CI: 3-45 months), whereas that of those with a 6MWD ≥ 330 m was 59 months (95% CI: 41-77 months; p = 0.009). Similarly, the median survival times of those with a 6MWD < 70% and ≥ 70% of predicted, respectively, were 24 months (95% CI: 13-35 months) and 59 months (95% CI: 38-80 months; p = 0.013). Cox multivariate regression models including age, sex, smoking status, SpO2 at the end of the 6MWT, and FVC% showed that 6MWD remained significantly associated with survival (p = 0.003).
conclusionsValues of 6MWD < 330 m and < 70% of predicted value were associated with lower survival time in IPF patients in Brazil.
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