ReviewWiley interdisciplinary reviews. Systems biology and medicine2019
Mathematical modeling of circadian rhythms.
Review in Wiley interdisciplinary reviews. Systems biology and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human melanopsin (OPN4) gene polymorphisms: a systematic review.Frontiers in neuroscience · 2025Pooled it
- A compartmentalized SCN model explains temperature resistance through interregional phase differences.PLoS computational biology · 2026Article
- Who Needs Bright Light and When? Mapping the Interactions of Lighting Environments and Individual Differences in Circadian Light Sensitivity.Journal of biological rhythms · 2026Article
- More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors.Epilepsia · 2025Article
- Circadian Regulation of Fatty Acid Metabolism in Humans: Is There Evidence of an Optimal Time Window for Maximizing Fat Oxidation During Exercise?Sports medicine (Auckland, N.Z.) · 2025Review
- Article
- Comparative Analysis of Methods of Evaluating Human Fatigue.Sleep science (Sao Paulo, Brazil) · 2024Article
- Computational modeling establishes mechanotransduction as a potent modulator of the mammalian circadian clock.Journal of cell science · 2024Article
- Article
- Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity.PLoS computational biology · 2024Article
- Predicting neurobehavioral performance of resident physicians in a Randomized Order Safety Trial Evaluating Resident-Physician Schedules (ROSTERS).Sleep health · 2024Article
- Environmental, social, and behavioral challenges of the human circadian clock in real-life conditions.Frontiers in physiology · 2024Article
- The Physiological and Pharmacological Significance of the Circadian Timing of the HPA Axis: A Mathematical Modeling Approach.Journal of pharmaceutical sciences · 2024Review
- Adaptive Circadian Rhythms for Autonomous and Biologically Inspired Robot Behavior.Biomimetics (Basel, Switzerland) · 2023Article
- 24-Hour Monitoring of Intraocular Pressure Fluctuations Using a Contact Lens Sensor: Diagnostic Performance for Glaucoma Progression.Investigative ophthalmology & visual science · 2023Article
- Non-contact robotic manipulation of floating objects: exploiting emergent limit cycles.Frontiers in robotics and AI · 2023Article
- Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations.Scientific reports · 2022Article
- Unstable eigenvectors and reduced amplitude spaces specifying limit cycles of coupled oscillators with simultaneously diagonalizable matrices: with applications from electric circuits to gene regulation.The European physical journal. B · 2022Article
- Circadian disruption and cancer- and treatment-related symptoms.Frontiers in oncology · 2022Review
- A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Circadian rhythms are endogenous ~24-hr oscillations usually entrained to daily environmental cycles of light/dark. Many biological processes and physiological functions including mammalian body temperature, the cell cycle, sleep/wake cycles, neurobehavioral performance, and a wide range of diseases including metabolic, cardiovascular, and psychiatric disorders are impacted by these rhythms. Circadian clocks are present within individual cells and at tissue and organismal levels as emergent properties from the interaction of cellular oscillators. Mathematical models of circadian rhythms have been proposed to provide a better understanding of and to predict aspects of this complex physiological system. These models can be used to: (a) manipulate the system in silico with specificity that cannot be easily achieved using in vivo and in vitro experimental methods and at lower cost, (b) resolve apparently contradictory empirical results, (c) generate hypotheses, (d) design new experiments, and (e) to design interventions for altering circadian rhythms. Mathematical models differ in structure, the underlying assumptions, the number of parameters and variables, and constraints on variables. Models representing circadian rhythms at different physiologic scales and in different species are reviewed to promote understanding of these models and facilitate their use. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.