Evidence map›Paper›PMID 30328620›Full record

ReviewCA: a cancer journal for clinicians2018

Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies.

David A Mahvi, Rong Liu, Mark W Grinstaff, Yolonda L Colson, Chandrajit P Raut

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CA: a cancer journal for clinicians, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07668362 (Clinicopathological Characteristics and Prognosis of Local Recurrence After Radical Mastectomy for Breast Cancer), which is not on this map. Cited by 171 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 4 pooled it
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07668362 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinicopathological Characteristics and Prognosis of Local Recurrence After Radical Mastectomy for Breast Cancer: A Prospective Cohort Study

TypeobservationalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2026 to 2036Enrolled100ConditionsBreast CancerArmsIndividualized therapy
3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 4 syntheses or guidelines pooled it, 343 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Identifying Locally Recurrent Versus Second Primary Breast Cancer: Genomic Versus Clinical Criteria from Carolina Breast Cancer Study Phase III.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Trial
  6. Article
  7. Review
  8. Amine-Functionalized and Gold-Decorated Amine-Functionalized TiOInternational journal of molecular sciences · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Biomedicines · 2026
    Article
  17. Review
  18. Article
  19. Review
  20. Review

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

David A MahviPostdoctoral Research Fellow, Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Rong LiuInstructor in Surgery, Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Mark W GrinstaffProfessor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine, Department of Chemistry, Boston University, Boston, MA.
Yolonda L ColsonMichael A. Bell Family Distinguished Chair in Healthcare Innovation and Professor of Surgery, Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Chandrajit P RautAssociate Professor of Surgery, Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · USBoston University · USHarvard University · US

Funding

TUMOR SPECIFIC DELIVERY OF VERTICILLIN A OVERCOMES EPIGENETIC SILENCING RESPONSIBLE FOR DRUG RESISTANCER01CA227433 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI COLSON, YOLONDA L, GRINSTAFF, MARK W. · 2018 to 2022
$2.7M
Efficacy and Safety of a Novel, Implantable Drug-eluting Film in SarcomaR01EB017722 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI COLSON, YOLONDA L, GRINSTAFF, MARK W. · 2016 to 2019
$1.7M
NIR Imaging of Sentinel Nodes in Lung Cancer: Finding MicrometastasesR01CA131044 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI COLSON, YOLONDA L · 2008 to 2011
$1.5M
NCI NIH HHS R01 CA131044NCI NIH HHS R01 CA227433NIBIB NIH HHS R01 EB017722
6 · The paper itself

Abstract

Locoregional recurrence negatively impacts both long-term survival and quality of life for several malignancies. For appropriate-risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life. For each type of cancer, the current, state-of-the-art treatment strategies and their outcomes are assessed. The need for additional therapeutic options is presented given the limitations of the current standard therapies. New and emerging treatment modalities, including polymer films and nanoparticles, are highlighted as potential future solutions for both prevention and treatment of locally recurrent cancers. Finally, the authors identify additional clinical and research opportunities and propose future research strategies based on the various patterns of local recurrence among the different cancers.

Indexed as

Quality of LifeCombined Modality TherapyHumansMedical OncologyNeoplasm Recurrence, LocalNeoplasmsRandomized Controlled Trials as TopicRisk FactorsTreatment Outcomebreast cancerdrug deliverylocal recurrencelung cancermesotheliomananoparticlesperitoneal surface malignanciespolymersrectal cancersarcoma

Identifiers

PMID30328620
PMCPMC6239861
OpenAlexW2897570149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.