Evidence map›Paper›PMID 30328613›Full record

ArticlePsychophysiology2020

Integrated genetic, epigenetic, and gene set enrichment analyses identify NOTCH as a potential mediator for PTSD risk after trauma: Results from two independent African cohorts.

Daniela Conrad, Sarah Wilker, Anna Schneider, Alexander Karabatsiakis, Anett Pfeiffer, Stephan Kolassa, Virginie Freytag, Vanja Vukojevic, Christian Vogler, Annette Milnik and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Daniela ConradClinical Psychology and Neuropsychology, University of Konstanz, Konstanz, Germany.
Sarah WilkerClinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Anna SchneiderClinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Alexander KarabatsiakisClinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Anett PfeifferClinical Psychology and Neuropsychology, University of Konstanz, Konstanz, Germany.
Stephan KolassaSAP Switzerland AG, Tägerwilen, Switzerland.
Virginie FreytagDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Vanja VukojevicDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Christian VoglerDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Annette MilnikDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Andreas PapassotiropoulosDivision of Molecular Neuroscience, University of Basel, Basel, Switzerland.
Dominique J-F de QuervainTransfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.
Thomas ElbertClinical Psychology and Neuropsychology, University of Konstanz, Konstanz, Germany.
Iris-Tatjana KolassaClinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
University of Basel · CHUniversität Ulm · DEUniversity of Konstanz · DESystems, Applications & Products in Data Processing (Switzerland) · CH

Funding

Swiss National Science Foundation 147570Swiss National Science Foundation 159740
6 · The paper itself

Abstract

The risk of developing posttraumatic stress disorder (PTSD) increases with the number of traumatic event types experienced (trauma load) in interaction with other psychobiological risk factors. The NOTCH (neurogenic locus notch homolog proteins) signaling pathway, consisting of four different trans-membrane receptor proteins (NOTCH1-4), constitutes an evolutionarily well-conserved intercellular communication pathway (involved, e.g., in cell-cell interaction, inflammatory signaling, and learning processes). Its association with fear memory consolidation makes it an interesting candidate for PTSD research. We tested for significant associations of common genetic variants of NOTCH1-4 (investigated by microarray) and genomic methylation of saliva-derived DNA with lifetime PTSD risk in independent cohorts from Northern Uganda (N

Indexed as

AdultCohort StudiesCpG IslandsDNA MethylationEpigenesis, GeneticHumansNerve Tissue ProteinsPolymorphism, Single NucleotidePsychological TraumaReceptor, Notch3RiskRwandaSignal TransductionStress Disorders, Post-TraumaticUgandaNerve Tissue ProteinsNOTCH3 protein, humanReceptor, Notch3candidate gene analysisepigeneticsgene set enrichment analysisMAGMANOTCHposttraumatic stress disorder

Identifiers

PMID30328613
PMCPMC7379258
OpenAlexW2897744504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.