Evidence map›Paper›PMID 30328574›Full record

ArticleJournal of assisted reproduction and genetics2019

Risk of prematurity and infant morbidity and mortality by maternal fertility status and plurality.

Barbara Luke, Morton B Brown, Ethan Wantman, David B Seifer, Amy T Sparks, Paul C Lin, Kevin J Doody, Bradley J Van Voorhis, Logan G Spector

Open access · bronzeAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.Journal of perinatology : official journal of the California Perinatal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Barbara LukeDepartment of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, 965 Fee Road, East Fee Hall, Room 628, East Lansing, MI, USA. lukeb@msu.edu.ORCID http://orcid.org/0000-0002-0405-8133
Morton B BrownDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Ethan WantmanRedshift Technologies, Inc., New York, NY, USA.
David B SeiferYale Fertility, Yale School of Medicine, New Haven, CT, USA.
Amy T SparksDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA.
Paul C LinSeattle Reproductive Medicine, Seattle, WA, USA.
Kevin J DoodyCenter for Assisted Reproduction, Bedford, TX, USA.
Bradley J Van VoorhisDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA, USA.
Logan G SpectorDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
University of Iowa · USCARE Fertility · USMichigan State University · USSeattle Reproductive Medicine · USUniversity of Michigan · USUniversity of Minnesota · US

Funding

Minnesota Population Center Science and Technical CoreP2CHD041023 · NICHD · UNIVERSITY OF MINNESOTA · PI THERESA LOUISE OSYPUK · 2016 to 2026
$4.3M
Assisted Reproductive Technology & Risk of Childhood CancerR01CA151973 · NCI · MICHIGAN STATE UNIVERSITY · PI LUKE, BARBARA JOAN, SPECTOR, LOGAN G. · 2011 to 2015
$3.0M
Assisted Reproduction and Child Health: Risk of Birth Defects, Mortality, and Effect on Grade School PerformanceR01HD084377 · NICHD · MICHIGAN STATE UNIVERSITY · PI LUKE, BARBARA JOAN · 2016 to 2020
$2.6M
National Cancer Institute R01CA151973NCI NIH HHS R01 CA151973NICHD NIH HHS P2C HD041023NICHD NIH HHS R01 HD084377
6 · The paper itself

Abstract

purposeTo evaluate the risk of prematurity and infant mortality by maternal fertility status, and for in vitro fertilization (IVF) pregnancies, by oocyte source and embryo state combinations.

methodsWomen in 14 States who had IVF-conceived live births during 2004-13 were linked to their infant's birth and death certificates; a 10:1 sample of non-IVF births was selected for comparison; those with an indication of infertility treatment on the birth certificate were categorized as subfertile, all others were categorized as fertile. Risks were modeled separately for the fertile/subfertile/IVF (autologous-fresh only) group and for the IVF group by oocyte source-embryo state combinations, using logistic regression, and reported as adjusted odds ratios (AORs) and 95% confidence intervals (CI).

resultsThe study population included 2,474,195 pregnancies. Placental complications (placenta previa, abruptio placenta, and other excessive bleeding) and prematurity were both increased with pregestational and gestational diabetes and hypertension, among subfertile and IVF groups, and in IVF pregnancies using donor oocytes. Both subfertile and IVF pregnancies were at risk for prematurity and NICU admission; IVF infants were also at risk for small-for-gestation birthweight, and subfertile infants had greater risks for neonatal and infant death. Within the IVF group, pregnancies with donor oocytes and/or thawed embryos were at greater risk of large-for-gestation birthweight, and pregnancies with thawed embryos were at greater risk of neonatal and infant death.

conclusionsPrematurity was associated with placental complications, diabetes and hypertension, subfertility and IVF groups, and in IVF pregnancies, donor oocytes and/or thawed embryos.

Indexed as

FertilityAdolescentAdultFemaleFertilization in VitroHumansInfant, NewbornInfant, Newborn, DiseasesInfertilityMaternal AgePlacenta DiseasesPregnancyPregnancy, MultiplePremature BirthRisk FactorsUnited StatesEmbryo stateFertility statusInfant morbidityInfant mortalityOocyte sourcePlacental complicationsPrematurity

Identifiers

PMID30328574
PMCPMC6338589
OpenAlexW2897168505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.