Trial reportJournal of assisted reproduction and genetics2019
The number of biopsied trophectoderm cells may affect pregnancy outcomes.
Trial report in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ESHRE recommendations on Good Practice in the IVF laboratory†.Human reproduction (Oxford, England) · 2026Guideline
- Double Zona Drilling for Trophectoderm Biopsy: A Safe Strategy When Inner Cell Mass Herniates.Diagnostics (Basel, Switzerland) · 2026Article
- Double versus single blastocyst biopsy and vitrification in preimplantation genetic testing (PGT) cycles: protocol for a systematic review and meta-analysis of clinical and neonatal outcomes.Systematic reviews · 2025Article
- A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testing.EBioMedicine · 2025Article
- Reproductive Choices in Haemoglobinopathies: The Role of Preimplantation Genetic Testing.Genes · 2025Review
- Trophectoderm Biopsy: Present State of the Art.Genes · 2025Review
- Impact of euploid blastocyst developmental stage and morphological grading on pregnancy outcomes in young recurrent pregnancy loss patients: association with parental chromosomal status.Frontiers in endocrinology · 2025Article
- Non Invasive Preimplantation Testing for Aneuploidies in Assisted Reproduction: A SWOT Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- PGT-A: what's it for, what's wrong?Journal of assisted reproduction and genetics · 2025Article
- Comparison of Non-Invasive and Minimally Invasive Preimplantation Genetic Testing for Aneuploidy Using Samples Derived from the Same Embryo Culture.Journal of clinical medicine · 2024Article
- Factors affecting biochemical pregnancy loss (BPL) in preimplantation genetic testing for aneuploidy (PGT-A) cycles: machine learning-assisted identification.Reproductive biology and endocrinology : RB&E · 2024Observational
- When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation.International journal of molecular sciences · 2024Review
- Influence of the number of washings for embryos on non-invasive preimplantation chromosome screening results.Frontiers in endocrinology · 2024Article
- Comparison of euploid blastocyst expansion with subgroups of single chromosome, multiple chromosome, and segmental aneuploids using an AI platform from donor egg embryos.Journal of assisted reproduction and genetics · 2023Observational
- Proceedings of the first world conference on AI in fertility.Journal of assisted reproduction and genetics · 2023Article
- Clinical application of noninvasive chromosomal screening for elective single-blastocyst transfer in frozen-thawed cycles.Journal of translational medicine · 2022Article
- An Update on Non-invasive Approaches for Genetic Testing of the Preimplantation Embryo.Current genomics · 2022Review
- Non-invasive preimplantation genetic testing for conventional IVF blastocysts.Journal of translational medicine · 2022Observational
- Article
- Associations among morphological parameters, clinical factors and euploid blastocyst formation.JBRA assisted reproduction · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study if the number of trophectoderm (TE) biopsied cells has an impact on implantation rates.
designA retrospective cohort study in a single-center study.
settingIn vitro fertilization center. PATIENTS: Patients who underwent PGT-A from January 2013 to March 2016. In total, 482 vitrified/warmed single embryo transfers were included.
interventionsNone.
main outcome measuresClinical pregnancies rate, implantation rate.
resultsOverall, clinical pregnancies per embryo transfer were higher when a regular TE were biopsied compared to larger size biopsy cells (66% (175/267) vs 53% (115/215) (p < 0.005) respectively). Pregnancy rates were also analyzed according to embryo morphology at the moment of embryo biopsy, when a good-quality embryo was transferred the clinical outcome was 75% (81/108) in group 1 and 61% (60/99) in group 2 (p < 0.05). Data was also stratified by age in patients ≤ 35 years and > 35 years. The clinical pregnancy was 67% (51/76) in women ≤ 35 years and 65% (124/191) in women > 35 years when a regular size biopsy was performed. These results significantly reduced when a larger size biopsy was performed 54% (49/91) and 53% (66/124), respectively (p < 0.05). Further investigation indicated that miscarriage rate was similar between these groups (4% (7/182) in group 1 and 5% (6/121) in group 2).
conclusionsThese findings underscore that when a large amount of TE cells are biopsied, it may negatively affect implantation rates, but once implanted, the embryos have the same chance to miscarry or reach term.
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