Evidence map›Paper›PMID 30328501›Full record

ArticleNeuroradiology2018

Thalamic and dentate nucleus abnormalities in the brain of children with Gaucher disease.

Giulia Perucca, Bruno P Soares, Serena Staglianò, James Davison, Anupam Chakrapani, Felice D'Arco

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Giulia PeruccaDivision of Pediatric Radiology, Regina Margherita Children's Hospital, Turin, Italy.
Bruno P SoaresDivision of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed Tower, Room 4174, Baltimore, MD, 21287, USA.
Serena StaglianòDepartment of Radiological Sciences, Institute of Radiology, Fondazione Policlinico Universitario A. Gemelli, School of Medicine, Catholic University, Largo A. Gemelli, 8, 00168, Rome, Italy.
James DavisonMetabolic Medicine Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Anupam ChakrapaniMetabolic Medicine Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Felice D'ArcoDepartment of Neuroradiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. darcofel@gmail.com.ORCID http://orcid.org/0000-0001-7396-591X
Great Ormond Street Hospital for Children NHS Foundation Trust · GBAgostino Gemelli University Polyclinic · ITJohns Hopkins University · USOspedale Regina Margherita · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gaucher disease (GD) represents the most common lysosomal storage defect. It is classified into three phenotypes: type 1 non-neuronopathic, type 2 acute neuronopathic, and type 3 subacute/chronic neuronopathic. Although children affected by GD may present with a broad spectrum of neurological signs, brain magnetic resonance imaging (MRI) findings are usually normal or non-specific. We report three cases of GD with previously undescribed brain MRI changes mainly affecting the thalami and/or the dentate nuclei. We discuss the possible etiopathogenesis of these abnormalities. Correlation between brain MRI abnormalities, neurological symptoms, and treatment efficacy is still unclear.

Indexed as

Cerebellar NucleiFatal OutcomeGaucher DiseaseHumansInfantMagnetic Resonance ImagingMalePhenotypeThalamusBrainDiffusion-weighted imagingGaucher diseaseLysosomal storage disordersMagnetic resonance imaging

Identifiers

PMID30328501
OpenAlexW2896630397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.