ArticleJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2019
Association of plasma haptoglobin concentration and other biomarkers with bovine respiratory disease status in pre-weaned dairy calves.
Article in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Associations between subclinical bovine respiratory disease, growth patterns, and the nasal and fecal microbiota in dairy replacement heifers: a retrospective study.Frontiers in veterinary science · 2026Article
- Pre-transport risk factors for severity of respiratory associated symptoms in unweaned calves following long-distance transport.Frontiers in veterinary science · 2026Article
- Article
- Clinical progression of a case of toe-tip necrosis syndrome in a feedlot steer.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- The Effect of Florfenicol Given by Nebulization in the Treatment of Naturally Infected Calves With Bovine Respiratory Disease Complex: Randomized Clinical Study.Veterinary medicine and science · 2025Article
- Cross-sectional study: can endogenous procalcitonin differentiate between healthy and bovine respiratory disease-affected preweaned dairy calves?The veterinary quarterly · 2024Article
- The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses.Tropical animal health and production · 2024Article
- Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview.Animals : an open access journal from MDPI · 2024Review
- Supplemental trace minerals as complexed or inorganic sources for beef cattle during the receiving period.Journal of animal science · 2024Article
- Article
- Dogs' ability to detect an inflammatory immune response in cattle via olfaction.Frontiers in veterinary science · 2024Article
- Auction market placement and a rest stop during transportation affect the respiratory bacterial microbiota of beef cattle.Frontiers in microbiology · 2023Article
- Nonparametric bootstrap methods for interval estimation of the area under the ROC curve with correlated diagnostic test data: application to whole-virus ELISA testing in swine.Frontiers in veterinary science · 2023Article
- The effects of administering different metaphylactic antimicrobials on growth performance and health outcomes of high-risk, newly received feedlot steers.Translational animal science · 2022Article
- Hematological and immunological responses to naturally occurring bovine respiratory disease in newly received beef calves in a commercial stocker farm.Journal of animal science · 2022Article
- Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) - preliminary study.BMC veterinary research · 2022Article
- Applying multi-omics data to study the genetic background of bovine respiratory disease infection in feedlot crossbred cattle.Frontiers in genetics · 2022Article
- Serum iron concentration is candidate inflammatory marker for respiratory diseases in beef cows.The Journal of veterinary medical science · 2021Article
- Cytokine and Haptoglobin Profiles From Shipping Through Sickness and Recovery in Metaphylaxis- or Un-Treated Cattle.Frontiers in veterinary science · 2021Article
- Changes in serum protein electrophoresis profiles and acute phase proteins in calves with diarrhea.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a nested, case-control study of pre-weaned dairy calves ( n = 477; 4 California dairy farms) to assess the association between bovine respiratory disease (BRD) and hematologic biomarkers, including plasma haptoglobin (Hp) and plasma bactericide (PB). At each location, heifer or bull dairy calves were observed 2-4 times per week until confirmed as BRD-positive using parallel interpretation of thoracic ultrasound examination and auscultation. In addition, control calves were enrolled after being confirmed as BRD-negative using ultrasound and auscultation. Complete blood counts (CBC), PB, and Hp concentrations were measured. Hp values were higher in calves with confirmed BRD than in controls ( p < 0.01). The area under the curve (AUC) for the various biomarkers was obtained from the corresponding receiver operating characteristic curves. The AUC for Hp was 0.68, a value greater than those for PB or the remaining CBC parameters, indicating that Hp may be the most useful biomarker of BRD in pre-weaned dairy calves. The cutoff value for Hp was 0.195 g/L.
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Registered trials
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