Evidence map›Paper›PMID 30328294›Full record

Trial reportInfluenza and other respiratory viruses2019

Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial.

Mark Loeb, Anh Duc Dang, Vu Dinh Thiem, Vitheya Thanabalan, Biao Wang, Nguyen Binh Nguyen, Hung Thi Mai Tran, Tan Minh Luong, Pardeep Singh, Marek Smieja and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 12 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 12 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mark LoebDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-2315-5390
Anh Duc DangNational Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Vu Dinh ThiemDepartment of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Vitheya ThanabalanDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Biao WangDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Nguyen Binh NguyenDepartment of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Hung Thi Mai TranDepartment of International Cooperation, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Tan Minh LuongNational Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Pardeep SinghDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Marek SmiejaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Jonathon MaguireSt. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Eleanor PullenayegumHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
McMaster University · CANational Institute Of Hygiene And Epidemiology · VNSt. Michael's Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is uncertain whether vitamin D can reduce respiratory infection.

objectiveTo determine whether vitamin D supplementation reduces influenza and other upper viral respiratory tract infections.

methodsA total of 1300 healthy children and adolescents between the ages of 3 and 17 years were randomized to vitamin D (14 000 U weekly) or placebo for 8 months in Vietnam. The primary outcome was reverse transcriptase (RT)-PCR-confirmed influenza infection, and the coprimary outcome was multiplex PCR-confirmed non-influenza respiratory viruses. Participants, caregivers, and those assessing outcomes were blinded to group assignment.

resultsA total of 650 children and adolescents were randomly assigned to vitamin D and 650 to placebo. The mean baseline serum 25-hydroxyvitamin D levels were 65.7 nmol/L and 65.2 nmol/L in the intervention and placebo groups, respectively, with an increase to 91.8 nmol/L in the vitamin D group and no increase, 64.5 nmol/L, in the placebo group. All 1300 participants randomized contributed to the analysis. We observed RT-PCR-confirmed influenza A or B occurred in 50 children (7.7%) in the vitamin D group and in 43 (6.6%) in the placebo group (hazard ratio [HR]: 1.18, 95% CI: 0.79-1.78). RT-PCR-confirmed non-influenza respiratory virus infection occurred in 146 (22.5%) in the vitamin D group and in 185 (28.5%) in the placebo group (hazard ratio [HR]: 0.76, 95% CI: 0.61-0.94). When considering all respiratory viruses, including influenza, the effect of vitamin D in reducing infection was significant, HR: 0.81, 95% CI: 0.66-0.99.

conclusionVitamin D supplementation did not reduce the incidence of influenza but moderately reduced non-influenza respiratory viral infection.

Indexed as

Dietary SupplementsAdolescentChildChild, PreschoolClinical Laboratory TechniquesDouble-Blind MethodFemaleHumansIncidenceInfluenza, HumanMaleOrthomyxoviridaeRespiratory Tract InfectionsVietnamVitamin DVitaminsVitamin DVitaminsinfluenzarandomized trialrespiratory virusesvitamin D

Identifiers

PMID30328294
PMCPMC6379634
OpenAlexW2897319957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.