ArticleInternational journal of geriatric psychiatry2019
Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults.
Article in International journal of geriatric psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health harms of non-medical prescription opioid use: A systematic review.Drug and alcohol review · 2022Pooled it
- The epidemiology of benzodiazepine misuse: A systematic review.Drug and alcohol dependence · 2019Pooled it
- Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism.Molecular psychiatry · 2019Trial
- Mortality Trends Associated With Acute Myocardial Infarction and Psychoactive Substance Use in Older Adults: A US Nationwide Analysis (1999-2020).Clinical cardiology · 2025Observational
- Self-Medication as a Global Health Concern: Overview of Practices and Associated Factors-A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Socio-demographic and toxicological findings from autoptic cases in a Northern Italy community (2017-2022).International journal of legal medicine · 2025Article
- The association of pain screening and pain level with suicide among US veterans with comorbid musculoskeletal and bipolar disorder diagnoses.Journal of affective disorders · 2025Article
- Factors associated with common mental disorders, suicidal risk, and stimulant use in college students.Revista brasileira de enfermagem · 2025Article
- The association of prescriber prominence in a shared-patient physician network with their patients receipt of and transitions between risky drug combinations.Applied network science · 2025Article
- Development and validation of a machine-learning model for the risk of potentially inappropriate medications in elderly stroke patients.Frontiers in pharmacology · 2025Article
- Sources of nonmedically used prescription psychotherapeutic drugs using real-world data from adolescents and adults assessed for substance use treatment--2014-2022.Research in social & administrative pharmacy : RSAP · 2024Article
- Mental and physical health characteristics of older and younger adults receiving medication for opioid use disorder.Frontiers in public health · 2024Article
- Transitions in Prescription Benzodiazepine Use and Misuse and in Substance Use Disorder Symptoms Through Age 50.Psychiatric services (Washington, D.C.) · 2023Article
- Developing a Warning Model of Potentially Inappropriate Medications in Older Chinese Outpatients in Tertiary Hospitals: A Machine-Learning Study.Journal of clinical medicine · 2023Article
- Article
- Depression, Suicidal Ideation, and Consumption of Psychotropic Drugs During Lockdown by COVID-19 According to Gender and Age.International journal of mental health and addiction · 2022Article
- Opioid poisoning cases aged 50+ in the 2015-2020 National Poisoning Data System: suspected suicides versus unintentional poisoning and other intentional misuse/abuse.Drug and chemical toxicology · 2022Article
- Exposure reasons, other substance use, and medical outcomes of poison control center cases aged 50+ involving opioids, 2015-2020.Clinical toxicology (Philadelphia, Pa.) · 2022Article
- Article
- Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations.Drugs & aging · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectivesSuicide in older adults is a major public health issue. Past research across the US adult population has linked prescription medication misuse with suicidal ideation. No work has evaluated associations between prescription opioid or benzodiazepine misuse and suicidal ideation in older adults, and this work aimed to address that gap. METHODS/
designData were from adults 50 years and older participating in the 2015 to 2016 National Survey on Drug Use and Health (n = 17 608). Design-based logistic regression evaluated links between any past-year prescription opioid or benzodiazepine use without misuse or prescription misuse and past-year suicidal ideation, after controlling for sociodemographic, physical health, mental health, and substance use correlates associated with suicidal ideation.
resultsAfter controlling for all correlates, past-year use without misuse of prescription opioids or benzodiazepines was not associated with past-year suicidal ideation in older adults. In contrast, past-year opioid misuse (AOR = 1.84, 95% CI = 1.07-3.19) and benzodiazepine misuse (AOR = 2.00, 95% CI = 1.01-3.94) were significantly associated with past-year suicidal ideation, even after controlling for all covariates. While 2.2% of US older adults not engaged in either opioid or benzodiazepine misuse reported past-year suicidal ideation, 25.4% of those who misused both medication classes endorsed such suicidality (AOR = 4.73, 95% CI = 2.07-10.79).
conclusionsBoth past-year prescription opioid and benzodiazepine misuse are associated with past-year suicidal ideation in US older adults. Clinicians encountering older adult patients at-risk for or engaged in prescription medication misuse also should screen for suicidality.
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Registered trials
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