ArticleDevelopmental psychobiology2019
Temporally sensitive neural measures of inhibition in preschool children across a spectrum of irritability.
Article in Developmental psychobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up.Development and psychopathology · 2019Trial
- Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control.Biological psychiatry global open science · 2025Article
- Leveraging technology to probe mechanisms of psychopathology: A proof of concept study of inhibitory control.PloS one · 2025Article
- An Expanded Conceptual Framework for Understanding Irritability in Childhood: The Role of Cognitive Control Processes.Clinical child and family psychology review · 2024Review
- Appetite hormone dysregulation and executive dysfunction among adolescents with bipolar disorder and disruptive mood dysregulation disorder.European child & adolescent psychiatry · 2024Article
- Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.Psychological medicine · 2023Article
- Prevalence, stability, and predictive utility of the Multidimensional Assessment of Preschoolers Scales clinically optimized irritability score: Pragmatic early assessment of mental disorder risk.International journal of methods in psychiatric research · 2023Article
- Incongruent affect in early childhood: Neurobiological markers and links to psychopathology.Emotion (Washington, D.C.) · 2023Article
- Irritability Moderates the Association between Cognitive Flexibility Task Performance and Related Prefrontal Cortex Activation in Young Children.Brain sciences · 2023Article
- Roads Diverged: Developmental Trajectories of Irritability From Toddlerhood Through Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Joint Consideration of Inhibitory Control and Irritability in Young Children: Contributions to Emergent Psychopathology.Research on child and adolescent psychopathology · 2022Article
- Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.Journal of psychopathology and clinical science · 2022Article
- Executive functioning moderates neural mechanisms of irritability during reward processing in youth.Psychiatry research. Neuroimaging · 2022Article
- Annual Research Review: The contributions of the RDoC research framework on understanding the neurodevelopmental origins, progression and treatment of mental illnesses.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
- The centrality of temperament to the research domain criteria (RDoC): The earliest building blocks of psychopathology.Development and psychopathology · 2021Article
- Network-wise surface-based morphometric insight into the cortical neural circuitry underlying irritability in adolescents.Translational psychiatry · 2021Article
- Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT.PloS one · 2021Article
- Neural and behavioral correlates of inhibitory control in youths with varying levels of irritability.Journal of affective disorders · 2020Article
- Understanding event-related potentials (ERPs) in clinical and basic language and communication disorders research: a tutorial.International journal of language & communication disorders · 2020Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Irritability is a prominent feature of chronic mental disorders and a developmental marker of their early emergence. The most salient feature of irritability in early childhood is temper tantrums. While temper tantrums are normative in young children, they can be clinically concerning when they are dysregulated, very frequent, and/or occur in unexpected contexts. The present study uses behavioral and event-related brain potential (ERP) measures to characterize the relationship between irritability and neural markers of response inhibition in very young children. Forty-six children (ages 4-7 years) completed a go/no-go task under nonfrustrating and frustrating conditions. ERPs elicited by go and no-go stimuli were examined as a function of frustration condition and irritability, operationalized via the well-validated Temper Loss scale of the Multidimensional Assessment Profile of Disruptive Behavior (MAP-DB). Higher Temper Loss scores were associated with larger N2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.