Evidence map›Paper›PMID 30328105›Full record

Trial reportThe Journal of physiology2019

Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions.

Justin J Kavanagh, Amelia J McFarland, Janet L Taylor

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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  9. The Effect of L-Tryptophan Intake on Dynamic Strength in Paralympic Powerlifting.International journal of tryptophan research : IJTR · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Justin J KavanaghMenzies Health Institute Queensland, Griffith University, Gold Coast, Australia.ORCID 0000-0002-1046-260X
Amelia J McFarlandSchool of Pharmacy and Pharmacology, Griffith University, Gold Coast, Australia.ORCID 0000-0002-4689-5028
Janet L TaylorSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.ORCID 0000-0001-8976-5162
Griffith University · AUEdith Cowan University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsAnimal preparations have revealed that moderate synaptic release of serotonin (5-HT) onto motoneurones enhances motor activity via activation of 5-HT ABSTRACT: Brief stimulation of the raphe-spinal pathway in the turtle spinal cord releases serotonin (5-HT) onto motoneurones to enhance excitability. However, intense release of 5-HT via prolonged stimulation results in 5-HT spillover to the motoneurone axon initial segment to activate inhibitory 5-HT

Indexed as

AdolescentAdultCross-Over StudiesDouble-Blind MethodElbowElectromyographyFemaleHumansMaleMotor NeuronsMuscle ContractionMuscle FatigueParoxetineSelective Serotonin Reuptake InhibitorsSerotoninTorqueParoxetineSelective Serotonin Reuptake InhibitorsSerotonincentral fatiguemonoamineMotoneurone

Identifiers

PMID30328105
PMCPMC6312415
OpenAlexW2900168537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.