ArticleFEBS letters2018
Anaerobic respiration coupled with mitochondrial fatty acid synthesis in wax ester fermentation by Euglena gracilis.
Article in FEBS letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Enhanced heterotrophic β-glucan production from a UV-induced Euglena gracilis mutant screened using a novel method under optimized cultivation conditions.Biotechnology for biofuels and bioproducts · 2025Article
- Metabolic changes and biochemical degradation during dark anoxic incubation of Nannochloropsis: implications for low-energy microalgal cell rupture.Bioprocess and biosystems engineering · 2025Article
- Fasting builds a favorable environment for effective gut microbiota modulation by microbiota-accessible carbohydrates.BMC microbiology · 2025Article
- Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism.Nature communications · 2024Article
- Glycosylated proteins in the protozoan alga Euglena gracilis: a proteomic approach.FEMS microbiology letters · 2023Article
- Article
- Induction of photosynthesis under anoxic condition inFrontiers in plant science · 2023Article
- The production of wax esters in transgenic plants: towards a sustainable source of bio-lubricants.Journal of experimental botany · 2022Review
- The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation.Scientific reports · 2021Article
- Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants.Frontiers in immunology · 2021Article
- Salt Stress Induces Paramylon Accumulation and Fine-Tuning of the Macro-Organization of Thylakoid Membranes inFrontiers in plant science · 2021Article
- The Cryptic Plastid ofmSphere · 2020Article
- Article
- Genetic Engineering Strategies forFrontiers in bioengineering and biotechnology · 2020Review
- Energy metabolism in anaerobic eukaryotes and Earth's late oxygenation.Free radical biology & medicine · 2019Review
- Noninvasive and safe cell viability assay forPeerJ · 2019Article
- Comparative proteomic analysis of mitochondria isolated from Euglena gracilis under aerobic and hypoxic conditions.PloS one · 2019Article
- Anti-fibrotic activity ofFood science & nutrition · 2019Article
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Euglena gracilis, wax ester fermentation produces ATP during anaerobiosis. Here, we report that anaerobic wax ester production is suppressed when the mitochondrial electron transport chain complex I is inhibited by rotenone, whereas it is increased by the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP). The ADP/ATP ratio in anaerobic cells is elevated by treatment with either rotenone or CCCP. Gene silencing experiments indicate that acyl-CoA dehydrogenase, electron transfer flavoprotein (ETF), and rhodoquinone (RQ) participate in wax ester production. These results suggest that fatty acids are synthesized in mitochondria by the reversal of β-oxidation, where trans-2-enoyl-CoA is reduced mainly by acyl-CoA dehydrogenase using the electrons provided by NADH via the electron transport chain complex I, RQ, and ETF, and that ATP production is highly supported by anaerobic respiration utilizing trans-2-enoyl-CoA as a terminal electron acceptor.
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