ArticleJournal of nephrology2019
Serum sodium concentration and the progression of established chronic kidney disease.
Article in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Biochemical Markers of Early Renal Dysfunction in Patients with β-thalassemia Major: A Systematic Review and Meta-analysis.Current medicinal chemistry · 2025Pooled it
- Comparison of AI-generated renal diets by different large language models: a guideline-based evaluation with expert input.BMC nephrology · 2026Article
- Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2025Article
- Development and validation of food frequency questionnaire screener software for sodium intake among palestinian population.BMC nutrition · 2024Article
- Ten tips on how to care for your CKD patients in episodes of extreme heat.Clinical kidney journal · 2024Review
- Personalizing electrolytes in the dialysis prescription: what, why and how?Clinical kidney journal · 2024Review
- Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease.Frontiers in endocrinology · 2024Article
- Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease.Renal failure · 2023Article
- Serum sodium levels associate with recovery of kidney function in immune checkpoint inhibitor nephrotoxicity.Frontiers in medicine · 2023Article
- Short and dysfunctional telomeres sensitize the kidneys to develop fibrosis.Nature aging · 2021Article
- Dysnatremias in Chronic Kidney Disease: Pathophysiology, Manifestations, and Treatment.Frontiers in medicine · 2021Review
- Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life.JCI insight · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigher serum sodium concentration has been reported to be a risk factor for the development of incident chronic kidney disease (CKD), but its relationship with the progression of established CKD has not been investigated. We hypothesised that increased serum sodium concentration is a risk factor for estimated glomerular filtration rate (eGFR) decline in CKD.
methodsThis was a retrospective cohort study using data collected over a 6-year period, with baseline data obtained during the first 2 years. We included patients known to our renal service who had had a minimum of three blood tests every 2 years and an eGFR of < 60 mL/min/1.73 m
results7418 blood results from 326 patients were included. There was no relationship between serum sodium concentration and estimated glomerular filtration rate at baseline. After multivariable adjustment, a 1 mmol/L increase in baseline serum sodium was associated with a 1.5 mL/min/1.73 m
conclusionHigher serum sodium concentration is associated with the progression of CKD, independently of other established risk factors. Conversely, significant alterations in serum sodium concentration do not occur with declining kidney function.
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Registered trials
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