Evidence map›Paper›PMID 30327997›Full record

ArticleAIDS and behavior2019

Vulnerable at Each Step in the PMTCT Care Cascade: High Loss to Follow Up During Pregnancy and the Postpartum Period in Tanzania.

Cody Cichowitz, Festo Mazuguni, Linda Minja, Prosper Njau, Gretchen Antelman, James Ngocho, Brandon A Knettel, Melissa H Watt, Blandina T Mmbaga

Abstract read
In one paragraph

Article in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cody CichowitzDuke Global Health Institute, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9029-6508
Festo MazuguniKilimanjaro Christian Medical University College, Moshi, Tanzania.
Linda MinjaKilimanjaro Clinical Research Institute, Box 2236, Moshi, Tanzania.
Prosper NjauKilimanjaro Christian Medical University College, Moshi, Tanzania.
Gretchen AntelmanElizabeth Glaser Pediatric AIDS Foundation, Dar es Salaam, Tanzania.
James NgochoKilimanjaro Christian Medical University College, Moshi, Tanzania.
Brandon A KnettelDuke Global Health Institute, Duke University, Durham, NC, USA.
Melissa H WattDuke Global Health Institute, Duke University, Durham, NC, USA.
Blandina T MmbagaKilimanjaro Clinical Research Institute, Box 2236, Moshi, Tanzania. b.mmbaga@kcri.ac.tz.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Sociobehavioral Sciences Research to Improve Care for HIV Infection in TanzaniaD43TW009595 · FIC · KILIMANJARO CHRISTIAN MEDICAL CENTRE · PI Blandina Theophil Mmbaga · 2013 to 2026
$4.2M
Strengthening of Research Capacity for Junior Faculty in TanzaniaD43TW010138 · FIC · KILIMANJARO CHRISTIAN MEDICAL COLLEGE · PI MTETA, ALFRED KIEN · 2015 to 2020
$3.2M
Postpartum HIV care engagement in the context of Option B+ in TanzaniaR21AI124344 · NIAID · DUKE UNIVERSITY · PI MMBAGA, BLANDINA THEOPHIL, WATT, MELISSA H · 2016 to 2017
$314k
Center for AIDS Research, Duke University P30 AI064518Doris Duke Charitable Foundation International Clinical Research FellowshipFIC NIH HHS D43 TW009595FIC NIH HHS D43 TW010138National Institute of Allergy and Infectious Diseases R21 AI124344NIAID NIH HHS P30 AI064518NIAID NIH HHS R21 AI124344
6 · The paper itself

Abstract

In 2013, Tanzania adopted the World Health Organization's Option B+ guidelines for prevention of mother-to-child transmission of HIV (PMTCT), whereby all HIV-infected pregnant women initiate lifelong antiretroviral therapy. This study examined retention in PMTCT across critical junctures in the care continuum. This was a retrospective study of patient-level data for a cohort of women enrolled in PMTCT during the first year of Option B+ in Tanzania. Retention in care was described across three periods: (1) the first month of antenatal care (ANC), (2) pregnancy, and (3) the postpartum period. Logistic regression was used to identify factors associated with loss to follow up (LTFU) during the first month of ANC. Survival analyses were used to identify factors associated with LTFU during pregnancy and the postpartum periods. 650 participants were included in the cohort; 262 (40.3%) were newly diagnosed with HIV. Two years after delivery, 383/650 (58.7%) were LTFU. Of the 383 LTFU, 73 (19.1%) were lost during the first month of ANC, 44 (11.5%) during pregnancy, and 266 (69.5%) after delivery. Being newly diagnosed with HIV predicted higher LTFU during the first month of ANC (aOR 1.76; 95% CI 1.06-2.94) and faster time to LTFU during the postpartum period (adjusted relative time, 0.68; 95% CI 0.51-0.89). High LTFU occurred across the PMTCT continuum, including immediately after enrollment into ANC and the postpartum period. Ongoing research is needed to encourage treatment uptake and sustained engagement after delivery.

Indexed as

Lost to Follow-UpPostpartum PeriodAcquired Immunodeficiency SyndromeAdultCohort StudiesContinuity of Patient CareFemaleHumansInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousPregnant PeoplePrenatal CareRetrospective StudiesTanzaniaWorld Health OrganizationHIVLTFUOption B+PMTCTRetention in careTanzania

Identifiers

PMID30327997
PMCPMC6467690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.