ArticleNanoscale research letters2018
Preparation of Glycyrrhetinic Acid Liposomes Using Lyophilization Monophase Solution Method: Preformulation, Optimization, and In Vitro Evaluation.
Article in Nanoscale research letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Construction and evaluation of liposomal drug delivery system for an ALK/HDACs dual-targeted inhibitor with sustained release and enhanced antitumor effect.Drug delivery and translational research · 2025Article
- Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension.Drug design, development and therapy · 2025Article
- Article
- Novel PEGylated cholephytosomes for targeting fisetin to breast cancer: in vitro appraisal and in vivo antitumoral studies.Drug delivery and translational research · 2024Article
- Combination of micelles and liposomes as a promising drug delivery system: a review.Drug delivery and translational research · 2023Review
- Lipid-hybrid cell-derived biomimetic functional materials: A state-of-the-art multifunctional weapon against tumors.Materials today. Bio · 2023Review
- Enhancement of the Bioavailability and Anti-Inflammatory Activity of Glycyrrhetinic Acid via Novel SoluplusPharmaceutics · 2022Article
- The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges.International journal of molecular sciences · 2022Review
- Development of Spanish Broom and Flax Dressings with Glycyrrhetinic Acid-Loaded Films for Wound Healing: Characterization and Evaluation of Biological Properties.Pharmaceutics · 2021Article
- Post-Processing Techniques for the Improvement of Liposome Stability.Pharmaceutics · 2021Review
- Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?Pharmacology & therapeutics · 2020Review
- Glycyrrhetinic Acid Liposomes and Hyalurosomes on Spanish Broom, Flax, and Hemp Dressings to Heal Skin Wounds.Molecules (Basel, Switzerland) · 2020Article
- Optimum Preparation Method for Self-Assembled PEGylation Nano-Adjuvant Based onInternational journal of nanomedicine · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In this study, glycyrrhetinic acid (GA) liposomes were successfully prepared using lyophilization monophase solution method. Preformulation studies comprised evaluation of solubility of soybean phosphatidylcholine (SPC), cholesterol, and GA in tert-butyl alcohol (TBA)/water co-solvent. The influences of TBA volume percentage on sublimation rate were investigated. GA after lyophilization using TBA/water co-solvent with different volume percentage was physicochemically characterized by DSC, XRD, and FTIR. The XRD patterns of GA show apparent amorphous nature. FTIR spectroscopy results show that no chemical structural changes occurred. Solubility studies show aqueous solubility of GA is enhanced. The optimum formulation and processing variables of 508 mg SPC, 151 mg cholesterol, 55% volume percentage of TBA, 4:1 trehalose/SPC weight ratio were obtained after investigating by means of Box-Benhnken design and selection experiment of lyoprotectant. Under the optimum conditions, satisfactory encapsulation efficiency (74.87%) and mean diameter (191 nm) of reconstituted liposomes were obtained. In vitro drug release study showed that reconstituted liposomes have sustained-release properties in two kinds of release medium. Furthermore, in vitro cell uptake study revealed that uptake process of drug-loaded liposomes by Hep G2 cells is time-dependent.
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