Evidence map›Paper›PMID 30327841›Full record

Trial reportWorld journal of surgery2019

Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients.

Kaij Treskes, Teun P Saltzherr, Michael J R Edwards, Benn J A Beuker, D Den Hartog, Joachim Hohmann, Jan S Luitse, Ludo F M Beenen, Markus W Hollmann, Marcel G W Dijkgraaf and 2 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01523626 (Randomized Study of Early Assessment by CT Scanning in Trauma Patients), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01523626 nacompletednot on this map

Randomized Study of Early Assessment by CT Scanning in Trauma Patients

TypeinterventionalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2011 to 2014Enrolled1,083ConditionsMultiple Trauma/InjuriesArmsTotal body Computed Tomography., Conventional imaging and selective CT scanning.
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Article
  6. Observational
  7. Outcome of severely injured patients in a unique trauma system with 24/7 double trauma surgeon on-call service.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023
    Article
  8. Current Standards for and Clinical Impact of Emergency Radiology in Major Trauma.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Kaij TreskesTrauma Unit, Department of Surgery, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands. k.treskes@amc.nl.
Teun P SaltzherrDepartment of Surgery, Haaglanden Medical Center, Lijnbaan 32, 2512 VA, Den Haag, Netherlands.
Michael J R EdwardsTrauma Unit, Department of Surgery, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen, Netherlands.
Benn J A BeukerTrauma Unit, Department of Surgery, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, Netherlands.
D Den HartogTrauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, Netherlands.
Joachim HohmannDepartment of Radiology and Nuclear Medicine, University of Basel Hospital, Petersgraben, 4031, Basel, Switzerland.
Jan S LuitseTrauma Unit, Department of Surgery, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.
Ludo F M BeenenDepartment of Radiology, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.
Markus W HollmannDepartment of Anaesthesiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.
Marcel G W DijkgraafClinical Research Unit, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.
J Carel GoslingsTrauma Unit, Department of Surgery, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.
REACT-2 study group
OLVG · NLUniversity of Amsterdam · NLAmsterdam University Medical Centers · NLAmsterdam UMC Location University of Amsterdam · NLErasmus MC · NLMedisch Centrum Haaglanden · NLRadboud University Nijmegen · NLUniversity Medical Center Groningen · NLUniversity of Basel · CH

Funding

ZonMw 171102023
6 · The paper itself

Abstract

backgroundImmediate total-body CT (iTBCT) is often used for screening of potential severely injured patients. Patients requiring emergency bleeding control interventions benefit from fast and optimal trauma screening. The aim of this study was to assess whether an initial trauma assessment with iTBCT is associated with lower mortality in patients requiring emergency bleeding control interventions.

methodsIn the REACT-2 trial, patients who sustained major trauma were randomized for iTBCT or for conventional imaging and selective CT scanning (standard workup; STWU) in five trauma centers. Patients who underwent emergency bleeding control interventions following their initial trauma assessment with iTBCT were compared for mortality and clinically relevant time intervals to patients that underwent the initial trauma assessment with the STWU.

resultsIn the REACT-2 trial, 1083 patients were enrolled of which 172 (15.9%) underwent emergency bleeding control interventions following their initial trauma assessment. Within these 172 patients, 85 (49.4%) underwent iTBCT as primary diagnostic modality during the initial trauma assessment. In trauma patients requiring emergency bleeding control interventions, in-hospital mortality was 12.9% (95% CI 7.2-21.9%) in the iTBCT group compared to 24.1% (95% CI 16.3-34.2%) in the STWU group (p = 0.059). Time to bleeding control intervention was not reduced; 82 min (IQR 5-121) versus 98 min (IQR 62-147), p = 0.108.

conclusionsReduction in mortality in trauma patients requiring emergency bleeding control interventions by iTBCT could not be demonstrated in this study. However, a potentially clinically relevant absolute risk reduction of 11.2% (95% CI - 0.3 to 22.7%) in comparison with STWU was observed.

trial registrationClinicalTrials.gov: NCT01523626.

Indexed as

Emergency Medical ServicesAdultFemaleHemorrhageHumansMaleMiddle AgedTomography, X-Ray ComputedWounds and Injuries

Identifiers

PMID30327841
PMCPMC6329725
OpenAlexW2897820012

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.