Evidence map›Paper›PMID 30327838›Full record

ReviewCellular and molecular life sciences : CMLS2019

Cerebrovascular disorders associated with genetic lesions.

Philipp Karschnia, Sayoko Nishimura, Angeliki Louvi

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Association of rareAnnals of translational medicine · 2022
    Article
  7. Review
  8. Article
  9. Apolipoprotein E and Atherosclerosis.Current atherosclerosis reports · 2021
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Philipp KarschniaDepartments of Neurosurgery and Neuroscience, Program on Neurogenetics, Yale School of Medicine, P.O. Box 208082, New Haven, CT, 06520-8082, USA.
Sayoko NishimuraDepartments of Neurosurgery and Neuroscience, Program on Neurogenetics, Yale School of Medicine, P.O. Box 208082, New Haven, CT, 06520-8082, USA.
Angeliki LouviDepartments of Neurosurgery and Neuroscience, Program on Neurogenetics, Yale School of Medicine, P.O. Box 208082, New Haven, CT, 06520-8082, USA. angeliki.louvi@yale.edu.ORCID http://orcid.org/0000-0003-1737-8707
Yale University · US

Funding

Functional Validation of Intracranial Aneurysm Risk GenesR01NS111935 · NINDS · YALE UNIVERSITY · PI GUNEL, MURAT, LOUVI, ANGELIKI · 2019 to 2023
$3.0M
Candidate Pharmacological Therapies for Cerebral Carvernous MalformationsR21NS105001 · NINDS · YALE UNIVERSITY · PI LOUVI, ANGELIKI · 2018 to 2019
$461k
NINDS NIH HHS R01 NS111935NINDS NIH HHS R21 NS105001
6 · The paper itself

Abstract

Cerebrovascular disorders are underlain by perturbations in cerebral blood flow and abnormalities in blood vessel structure. Here, we provide an overview of the current knowledge of select cerebrovascular disorders that are associated with genetic lesions and connect genomic findings with analyses aiming to elucidate the cellular and molecular mechanisms of disease pathogenesis. We argue that a mechanistic understanding of genetic (familial) forms of cerebrovascular disease is a prerequisite for the development of rational therapeutic approaches, and has wider implications for treatment of sporadic (non-familial) forms, which are usually more common.

Indexed as

Adenosine TriphosphatasesAmyloid beta-Protein PrecursorCADASILCerebral Amyloid AngiopathyCerebral Small Vessel DiseasesCerebrovascular DisordersHumansMoyamoya DiseaseReceptor, Notch3SOXF Transcription FactorsUbiquitin-Protein LigasesAdenosine TriphosphatasesAmyloid beta-Protein PrecursorReceptor, Notch3RNF213 protein, humanSOX17 protein, humanSOXF Transcription FactorsUbiquitin-Protein LigasesCerebrovascular diseaseGeneticsHemorrhagic cerebrovascular diseaseModel organismsSmall vessel disease

Identifiers

PMID30327838
PMCPMC6450555
OpenAlexW2896930341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.