ArticleHuman genetics1987
Construction of a human ventricular cDNA library and characterization of a beta myosin heavy chain cDNA clone.
Article in Human genetics, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Isolation and localization of the skeletal myosin heavy chain 2X gene on pig chromosome 12q1.4-q1.5.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Complete sequence and organization of the human cardiac beta-myosin heavy chain gene.Nucleic acids research · 1990Article
- Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Characterization of human cardiac myosin heavy chain genes.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Isolation and characterization of the complete human beta-myosin heavy chain gene.Human genetics · 1989Article
- Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.The Journal of clinical investigation · 1988Article
- Two different forms of beta myosin heavy chain are expressed in human striated muscle.Human genetics · 1987Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have constructed and characterized for the first time a complementary DNA (cDNA) clone, pHMC3, which codes for a cardiac myosin heavy chain mRNA from human heart. This clone contains a 1.7 kb DNA segment and specifies 543 amino acids of the carboxyl portion of the myosin heavy chain. The DNA sequence and encoded amino acid sequence were compared to the hamster alpha (pVHC1) and beta (pVHC2/pVHC3) cardiac myosin heavy chain cDNA and amino acid sequences and the rat cardiac myosin heavy chain sequences as well. The myosin heavy chain mRNAs are highly conserved and this is reflected in our cDNA clone. The pHMC3 clone is 87.9% homologous to the hamster alpha cDNA and 92.2% homologous to the hamster beta cDNA clones. The 3' untranslated region of pHMC3 is 64.1% homologous to the hamster beta clone while the hamster alpha myosin heavy chain shows only 25% homology to pHMC3 and exhibits extensive diversity. Similar results were obtained when pHMC3 was compared to the rat cardiac myosin heavy chain cDNA sequences. The comparisons showed that pHMC3 is a beta cardiac myosin heavy chain cDNA clone.
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