Evidence map›Paper›PMID 30327676›Full record

ArticleJournal of environmental and public health2018

Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations.

Larisa M Gearhart-Serna, Nishad Jayasundara, Moises Tacam, Richard Di Giulio, Gayathri R Devi

Open access · hybridAbstract read
In one paragraph

Article in Journal of environmental and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects.International journal of environmental research and public health · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Environmental Quality and Invasive Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Larisa M Gearhart-SernaDepartment of Surgery, Division of Surgical Sciences, Duke Cancer Institute, Duke University, Durham, NC, USA.
Nishad JayasundaraNicholas School of the Environment, Duke Cancer Institute, Duke University, Durham, NC, USA.
Moises TacamTrinity School of Arts and Sciences, Duke Cancer Institute, Duke University, Durham, NC, USA.
Richard Di GiulioNicholas School of the Environment, Duke Cancer Institute, Duke University, Durham, NC, USA.
Gayathri R DeviDepartment of Surgery, Division of Surgical Sciences, Duke Cancer Institute, Duke University, Durham, NC, USA.ORCID 0000-0001-9158-7289
Duke University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Project 2: Identifying and modulating genetic modifiers of GLI1 activation in inflammatory breast cancer.P20CA202924 · NCI · NORTH CAROLINA CENTRAL UNIVERSITY · PI WILLIAMS, KEVIN PETER · 2016 to 2019
$870k
NCI NIH HHS P20 CA202924NCI NIH HHS P30 CA014236NIEHS NIH HHS T32 ES021432
6 · The paper itself

Abstract

Polycyclic aromatic hydrocarbon (PAH) exposure is widespread, and many PAHs are considered carcinogenic. The PAH-contaminated AWI Superfund site in Virginia provides a model for studying a complex PAH mixture and its extrapolation to cancer risk and PAH exposure in the general population. We examined cancer risk at the Superfund site due to sediment-derived PAHs and then evaluated PAH sources in the general population and potentially vulnerable subpopulations upon PAH mixture exposure. The PAH mixture was assessed for potential carcinogenicity using the US EPA's OncoLogic™ ranking tool and the US EPA list of priority PAHs. Cancer risk due to PAH exposure was calculated for Superfund site users and compared to the US EPA assessment. Human intake and health endpoints of PAHs within the mixture were extracted from USEtox® chemical fate database, while mean intake exposure was calculated for U.S. adults for select PAHs using NHANES database urinary biomarkers. Eleven PAH compounds within the mixture were of carcinogenic concern, and seven PAHs conveyed significant excess cancer risk at the Superfund site and in the general population, wherein PAH-contaminated seafood ingestion was a main contributor. Other dietary sources of PAHs derived from PAH-contaminated soil or water could also play a role in total exposure. Vulnerable populations to PAH exposure and coinciding increased cancer risk may include, in addition to smokers, children and non-Hispanic blacks, which is a public health concern.

Indexed as

DietEnvironmental ExposureGeologic SedimentsHumansModels, TheoreticalNeoplasmsPolycyclic Aromatic HydrocarbonsRisk AssessmentVirginiaVulnerable PopulationsWater Pollutants, ChemicalPolycyclic Aromatic HydrocarbonsWater Pollutants, Chemical

Identifiers

PMID30327676
PMCPMC6169233
OpenAlexW2889668329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.