Evidence map›Paper›PMID 30327651›Full record

ArticleFrontiers in immunology2018

Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.

Mei Qiu Lim, Emmanuelle A P Kumaran, Hwee Cheng Tan, David C Lye, Yee Sin Leo, Eng Eong Ooi, Paul A MacAry, Antonio Bertoletti, Laura Rivino

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mei Qiu LimProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Emmanuelle A P KumaranImmunology Programme, Department of Microbiology and Immunology, Life Science Institute, National University of Singapore, Singapore, Singapore.
Hwee Cheng TanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
David C LyeCommunicable Disease Centre, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore.
Yee Sin LeoCommunicable Disease Centre, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore.
Eng Eong OoiProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Paul A MacAryImmunology Programme, Department of Microbiology and Immunology, Life Science Institute, National University of Singapore, Singapore, Singapore.
Antonio BertolettiProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Laura RivinoProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
National University of Singapore · SGDuke-NUS Medical School · SGSingapore Immunology Network · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV), a flavivirus with homology to dengue virus (DENV), is spreading to areas of DENV hyper-endemicity. Heterologous T cell immunity, whereby virus-specific memory T cells are activated by variant peptides derived from a different virus, can lead to enhanced viral clearance or diminished protective immunity and altered immunopathology. In mice, CD8+ T cells specific for DENV provide

Indexed as

Immunologic MemoryCapsidCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCross ReactionsCytokinesDEAD-box RNA HelicasesDengueDengue VirusEpitopes, T-LymphocyteHumansImmunity, HeterologousNucleoside-TriphosphataseRNA HelicasesSerine EndopeptidasesCytokinesDEAD-box RNA HelicasesEpitopes, T-LymphocyteNS3 protein, flavivirusNucleoside-TriphosphataseRNA HelicasesSerine EndopeptidasesViral Nonstructural ProteinsViral Proteasesanti-viral responsecross-reactive immune responsedengue virus (DENV)heterologous immunityT cellsZika virus (ZIKV)

Identifiers

PMID30327651
PMCPMC6174860
OpenAlexW2895706567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.