Evidence map›Paper›PMID 30327649›Full record

ArticleFrontiers in immunology2018

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin.

Sokratis A Apostolidis, Giuseppina Stifano, Tracy Tabib, Lisa M Rice, Christina M Morse, Bashar Kahaleh, Robert Lafyatis

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Silencing APLNR enhances the radiosensitivity of prostate cancer by modulating the PI3K/AKT/mTOR signaling pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sokratis A ApostolidisDivision of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Giuseppina StifanoBoston University School of Medicine, Boston, MA, United States.
Tracy TabibDivision of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Lisa M RiceBoston University School of Medicine, Boston, MA, United States.
Christina M MorseDivision of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Bashar KahalehDivision of Rheumatology and Immunology, Department of Medicine, University of Toledo, Toledo, OH, United States.
Robert LafyatisDivision of Rheumatology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
University of Pittsburgh Medical Center · USBoston University · USUniversity of Toledo · US

Funding

Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesisP50AR060780 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAFYATIS, ROBERT A. · 2011 to 2021
$14.9M
NIAMS NIH HHS P50 AR060780
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Apelin ReceptorsBase SequenceBiomarkersBiopsyComplement ActivationEndothelial CellsEpithelial-Mesenchymal TransitionExtracellular MatrixGene ExpressionHeparan Sulfate ProteoglycansHumansImmunohistochemistryMatrix MetalloproteinasesNeovascularization, PathologicScleroderma, SystemicSequence Analysis, RNAApelin ReceptorsAPLNR protein, humanBiomarkersHeparan Sulfate ProteoglycansMatrix MetalloproteinasesperlecanAPLNRendothelial dysfunctionHSPG2ScRNA-seqsystemic sclerosis

Identifiers

PMID30327649
PMCPMC6174292
OpenAlexW2894799848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.