ReviewFrontiers in psychiatry2018
Marijuana Use and Hypothalamic-Pituitary-Adrenal Axis Functioning in Humans.
Review in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study.Cannabis and cannabinoid research · 2024Trial
- Sex-specific effects of low-dose hydrocortisone on threat detection in HIV.Journal of neurovirology · 2021Trial
- Non-Psychoactive Cannabis Extract Disrupts Reinstatement and Reconsolidation in Cocaine-Induced Conditioned Place Preference in Mice.Brain sciences · 2026Article
- Medicinal Plants for Major Depressive Disorder.Brain sciences · 2026Review
- Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Translational psychiatry · 2024Article
- Bidirectional associations between sleep and cannabis and alcohol (co-)use in daily life.Alcohol, clinical & experimental research · 2024Article
- Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals.Psychological medicine · 2024Article
- Chronic Δ9-tetrahydrocannabinol treatment has dose-dependent effects on open field exploratory behavior and [Life sciences · 2023Article
- Sex differences in neuroendocrine, sympathetic nervous system, and affect responses to acute stress in cannabis users.Psychopharmacology · 2023Article
- Sex and drug differences in stress, craving and cortisol response to the trier social stress task.Psychopharmacology · 2022Article
- Sex moderates effects of alcohol and cannabis co-use on alcohol and stress reactivity.Alcoholism, clinical and experimental research · 2022Article
- The Cortisol Assessment List (CoAL) A tool to systematically document and evaluate cortisol assessment in blood, urine and saliva.Comprehensive psychoneuroendocrinology · 2022Review
- Machine Learning-Based Texture Analysis in the Characterization of Cortisol Secreting vs. Non-Secreting Adrenocortical Incidentalomas in CT Scan.Frontiers in endocrinology · 2022Article
- A review of the effects of acute and chronic cannabinoid exposure on the stress response.Frontiers in neuroendocrinology · 2021Review
- Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development.International journal of molecular sciences · 2021Review
- Development of central precocious puberty following cannabinoid use for paediatric epilepsy: causal or coincidence?BMJ case reports · 2021Article
- Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping.Frontiers in psychology · 2021Review
- A systematic review of the Trier Social Stress Test methodology: Issues in promoting study comparison and replicable research.Neurobiology of stress · 2020Review
- Maternal persistent marijuana use and cigarette smoking are independently associated with shorter gestational age.Paediatric and perinatal epidemiology · 2020Article
- Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preclinical studies suggest cannabinoids affect functioning of the hypothalamic-pituitary-adrenal (HPA) axis, but little is known about the effects of marijuana (MJ) use on HPA axis functioning in humans. Since previous work indicates substances of abuse may dysregulate the HPA axis, it is critical to understand how MJ use affects HPA axis activity. Here, we review studies that (a) examined the effects of acute MJ administration on HPA axis functioning, (b) investigated the impact of stress on HPA axis functioning in MJ users, (c) examined the effect of chronic MJ use on basal cortisol levels, and (d) studied the relationship between MJ use and the cortisol awakening response (CAR). Findings indicate acute MJ administration typically raises cortisol levels, but this increase is blunted in MJ-dependent users relative to controls. Frequent MJ users have blunted adrenocorticotropic hormone and cortisol reactivity in response to acute stress. These findings suggest HPA axis activity may be dysregulated by heavy MJ use. Alternatively, dysregulation of the HPA axis may be a risk marker for heavy MJ use. There is mixed evidence for how MJ use affects basal cortisol levels and the CAR. Future studies should consider MJ use characteristics, method of hormone collection, time when samples are collected, and environmental factors that may influence HPA axis activity in MJ users. By examining existing studies we provide one of the first reviews aimed at synthesizing the literature on HPA axis functioning in MJ users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.