ArticleActa pharmacologica Sinica2019
Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions.
Article in Acta pharmacologica Sinica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule.Acta pharmacologica Sinica · 2021Trial
- Effects of Shenmai Injection on the Pharmacokinetics of Dasatinib: An In-DepthCurrent drug metabolism · 2024Article
- Ginsenoside Rg1 in neurological diseases: From bench to bedside.Acta pharmacologica Sinica · 2023Review
- Hot Air Impingement Drying Enhanced Drying Characteristics and Quality Attributes ofFoods (Basel, Switzerland) · 2023Article
- Anaphylactoid reactions induced by Shuanghuanglian injection and Shenmai injection and metabolomics analysis.Frontiers in pharmacology · 2023Article
- Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines.Acta pharmacologica Sinica · 2022Review
- Novel assays for quality evaluation of XueBiJing: Quality variability of a Chinese herbal injection for sepsis management.Journal of pharmaceutical analysis · 2022Article
- Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids ofFrontiers in pharmacology · 2022Article
- Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics.International journal of molecular sciences · 2021Review
- Spectrum-effect relationship between UPLC fingerprints and anti-lung cancer effect of Panax ginseng.Phytochemical analysis : PCA · 2021Article
- Shenmai injection enhances cisplatin-induced apoptosis through regulation of Mfn2-dependent mitochondrial dynamics in lung adenocarcinoma A549/DDP cells.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- Review
- Virtual screening and network pharmacology-based synergistic mechanism identification of multiple components contained in Guanxin V against coronary artery disease.BMC complementary medicine and therapies · 2020Article
- Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics.Acta pharmaceutica Sinica. B · 2020Article
- The Inhibition Effects of Shenmai Injection on Acetylcholine-Induced Catecholamine Synthesis and Secretion by Modulating Nicotinic Acetylcholine Receptor Ion Channels in Cultured Bovine Adrenal Medullary Cells.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions.Chinese medicine · 2020Article
- Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions.Acta pharmacologica Sinica · 2019Article
- High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care.Acta pharmaceutica Sinica. B · 2019Article
- Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang.Evidence-based complementary and alternative medicine : eCAM · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ShenMai, an intravenous injection prepared from steamed Panax ginseng roots (Hongshen) and Ophiopogon japonicus roots (Maidong), is used as an add-on therapy for coronary artery disease and cancer; saponins are its bioactive constituents. Since many saponins inhibit human organic anion-transporting polypeptides (OATP)1B, this investigation determined the inhibition potencies of circulating ShenMai saponins on the transporters and the joint potential of these compounds for ShenMai-drug interaction. Circulating saponins and their pharmacokinetics were characterized in rats receiving a 30-min infusion of ShenMai at 10 mL/kg. Inhibition of human OATP1B1/1B3 and rat Oatp1b2 by the individual saponins was investigated in vitro; the compounds' joint inhibition was also assessed in vitro and the data was processed using the Chou-Talalay method. Plasma protein binding was assessed by equilibrium dialysis. Altogether, 49 saponins in ShenMai were characterized and graded into: 10-100 μmol/day (compound doses from ShenMai; 7 compounds), 1-10 μmol/day (17 compounds), and <1 μmol/day (25 compounds, including Maidong ophiopogonins). After dosing, circulating saponins were protopanaxadiol-type ginsenosides Rb
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