Evidence map›Paper›PMID 30327434›Full record

ArticleThe Journal of biological chemistry2018

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.

Emily T Camilleri, Amel Dudakovic, Scott M Riester, Catalina Galeano-Garces, Christopher R Paradise, Elizabeth W Bradley, Meghan E McGee-Lawrence, Hee-Jeong Im, Marcel Karperien, Aaron J Krych and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Emily T CamilleriFrom the Departments of Orthopedic Surgery.ORCID 0000-0001-8982-6770
Amel DudakovicFrom the Departments of Orthopedic Surgery.
Scott M RiesterFrom the Departments of Orthopedic Surgery.
Catalina Galeano-GarcesFrom the Departments of Orthopedic Surgery.
Christopher R ParadiseFrom the Departments of Orthopedic Surgery.
Elizabeth W BradleyFrom the Departments of Orthopedic Surgery.
Meghan E McGee-Lawrencethe Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Hee-Jeong Imthe Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, and.
Marcel Karperienthe Department of Developmental BioEngineering, University of Twente, 7522 NB Enschede, The Netherlands.
Aaron J KrychFrom the Departments of Orthopedic Surgery.
Jennifer J WestendorfFrom the Departments of Orthopedic Surgery.ORCID 0000-0002-4464-6108
A Noelle LarsonFrom the Departments of Orthopedic Surgery.
Andre J van WijnenFrom the Departments of Orthopedic Surgery, vanwijnen.andre@mayo.edu.ORCID 0000-0002-4458-0946
Mayo Clinic · USAugusta University · USJesse Brown VA Medical Center · USUniversity of Twente · NL

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Molecular Control of Bone FormationR01AR049069 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WESTENDORF, JENNIFER J · 2003 to 2021
$5.8M
Validation of Novel Target for OA TreatmentR01AR077890 · NIAMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROYSTON, THOMAS J · 2020 to 2020
$4.2M
Protein Phosphatase Phlpp1 in Cartilage Development & Osteoarthritis ProgressionR01AR068103 · NIAMS · MAYO CLINIC ROCHESTER · PI WESTENDORF, JENNIFER J · 2014 to 2018
$1.9M
Epigenetic Regulation of Phlpp1 in Cartilage Development and RegenerationK01AR065397 · NIAMS · MAYO CLINIC ROCHESTER · PI BRADLEY, ELIZABETH W · 2014 to 2018
$440k
Epigenetic Modulation of the Epiphyseal Growth Plate to Treat Pediatric Limb DeformitiesR03AR066342 · NIAMS · MAYO CLINIC ROCHESTER · PI LARSON, ANNALISE NOELLE · 2014 to 2016
$239k
Epigenetic control of osteoblast differentiationF32AR066508 · NIAMS · MAYO CLINIC ROCHESTER · PI DUDAKOVIC, AMEL · 2015 to 2017
$185k
BLRD VA I01 BX002647NCATS NIH HHS UL1 TR000135NIAMS NIH HHS F32 AR066508NIAMS NIH HHS K01 AR065397NIAMS NIH HHS R01 AR049069NIAMS NIH HHS R01 AR068103NIAMS NIH HHS R01 AR077890NIAMS NIH HHS R03 AR066342
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCartilageCell DifferentiationChondrocytesChondrogenesisEnhancer of Zeste Homolog 2 ProteinGene Knockdown TechniquesHistonesLysineMethylationMiceOsteogenesisTranscriptomeEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistonesLysinechondrocyteconditional knockout mousedevelopmentepigeneticshistonehistone methylationmesenchymal stem cells (MSCs)skeletal development

Identifiers

PMID30327434
PMCPMC6295726
OpenAlexW2897421621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.