Evidence map›Paper›PMID 30327433›Full record

ArticleThe Journal of biological chemistry2018

Discovery of the actinoplanic acid pathway in

Peter Mrak, Philipp Krastel, Petra Pivk Lukančič, Jianshi Tao, Dominik Pistorius, Charles M Moore

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
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  11. Review
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  13. Crossroads of Antibiotic Resistance and Biosynthesis.Journal of molecular biology · 2019
    Review
  14. Mining bacterial genomes to reveal secret synergy.The Journal of biological chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peter MrakFrom the Novartis Technical Operations, Antiinfectives, SI-1234 Mengeš, Slovenia,; University of Ljubljana, 1000 Ljubljana, Slovenia. Electronic address: peter.mrak@novartis.com.
Philipp KrastelNovartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
Petra Pivk LukančičFrom the Novartis Technical Operations, Antiinfectives, SI-1234 Mengeš, Slovenia.
Jianshi TaoGenomics Institute of the Novartis Research Foundation, San Diego, California 92121, and.
Dominik PistoriusNovartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland.
Charles M MooreNovartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland,. Electronic address: charles-1.moore@novartis.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinobacteria possess a great wealth of pathways for production of bioactive compounds. Following advances in genome mining, dozens of natural product (NP) gene clusters are routinely found in each actinobacterial genome; however, the

Indexed as

Biosynthetic PathwaysMultigene FamilyLactonesMethylationPolyketidesSecondary MetabolismSirolimusStreptomycesactinoplanic acid ALactonesPolyketidesSirolimusactinobacteriaactinoplanic acidgenomicsnatural product biosynthesispathwaypeptide biosynthesispolyketideprotein farnesylationrapamycinsynergytarget of rapamycin (TOR)tricarboxylic acid cycle (TCA cycle) (Krebs cycle)

Identifiers

PMID30327433
PMCPMC6311506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.