ArticleDiabetes2019
Glycemic Variability and Brain Glucose Levels in Type 1 Diabetes.
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Reversibility of brain glucose kinetics in type 2 diabetes mellitus.Diabetologia · 2022Trial
- Measurement of brain glucose metabolism in obesity and diabetes.Diabetologia · 2025Review
- Association between cerebral lesions and the severity of diabetic cardiovascular disease, retinopathy, and nephropathy-new lessons to learn from neuroimaging.Journal of endocrinological investigation · 2025Review
- Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes.Communications biology · 2025Article
- Review
- Clinical relevance of short-term glycemic variability in children and adolescents with type 1 diabetes: a narrative review.Translational pediatrics · 2024Review
- Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?Therapeutic advances in chronic disease · 2024Review
- STZ-induced hyperglycemia differentially influences mitochondrial distribution and morphology in the habenulointerpeduncular circuit.Frontiers in cellular neuroscience · 2024Article
- Article
- Brain Glucose Sensing and the Problem of Relative Hypoglycemia.Diabetes care · 2023Review
- The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis.Cell & bioscience · 2022Review
- Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats.International journal of molecular sciences · 2021Article
- Glucose metabolic crosstalk and regulation in brain function and diseases.Progress in neurobiology · 2021Review
- Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens.Diabetes · 2021Article
- Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis.Scientific reports · 2021Article
- Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices.Frontiers in synaptic neuroscience · 2021Article
- Review
- Interaction of glucose sensing and leptin action in the brain.Molecular metabolism · 2020Review
- Transient gain of function of cannabinoid CBBrain research bulletin · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Janice J HwangSection of Endocrinology, Yale School of Medicine, New Haven, CT janice.hwang@yale.edu.ORCID 0000-0002-8395-5659
Lihong JiangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
Elizabeth Sanchez RangelSection of Endocrinology, Yale School of Medicine, New Haven, CT.
Xiaoning FanSection of Endocrinology, Yale School of Medicine, New Haven, CT.
Yuyan DingSection of Endocrinology, Yale School of Medicine, New Haven, CT.
Wai LamSection of Endocrinology, Yale School of Medicine, New Haven, CT.
Jessica LeventhalSection of Endocrinology, Yale School of Medicine, New Haven, CT.
Feng DaiYale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT.
Douglas L RothmanDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
Graeme F MasonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
Robert S SherwinSection of Endocrinology, Yale School of Medicine, New Haven, CT.
Yale University · US
Funding
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0MInstitutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2MDIABETES MELLITUS &DISORDERS OF METABOLISMT32DK007058 · NIDDK · YALE UNIVERSITY · PI SONIA CAPRIO, Kevan C Herold · 1986 to 2026
$9.6MGLUCOREGULATORY HORMONE INTERACTIONS IN DIABETESR01DK020495 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, DOUGLAS LYLE · 1986 to 2022
$6.6MCareer Development Programs in Diabetes Research for Pediatrics EndocrinologistsK12DK094714 · NIDDK · YALE UNIVERSITY · PI TAMBORLANE, WILLIAM V · 2011 to 2020
$4.3MYale University Clinical and Translational Science Award ProgramKL2TR000140 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$2.9MBrain Acetate and Ethanol Metabolism in Alcohol Dependence and AbuseR01AA021984 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2013 to 2017
$2.7M13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1MComprehensive, Cross Platform-Validated 13C Flux Measures of Intra-and Inter-tissue MetabolismR01DK108283 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MASON, GRAEME F. · 2016 to 2019
$2.1MInvestigating the polyol pathway in the human brainK23DK109284 · NIDDK · YALE UNIVERSITY · PI HWANG, JANICE JIN · 2016 to 2019
$758kConsole for 4T Human MR SystemS10OD010613 · OD · YALE UNIVERSITY · PI ROTHMAN, DOUGLAS LYLE · 2012 to 2012
$599kNCATS NIH HHS KL2 TR000140NCATS NIH HHS KL2 TR001862NCRR NIH HHS UL1 RR024139NIAAA NIH HHS R01 AA021984NIDDK NIH HHS K12 DK094714NIDDK NIH HHS K23 DK109284NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK020495NIDDK NIH HHS R01 DK108283NIDDK NIH HHS T32 DK007058NIH HHS S10 OD010613NINDS NIH HHS R01 NS087568
Abstract
The impact of glycemic variability on brain glucose transport kinetics among individuals with type 1 diabetes mellitus (T1DM) remains unclear. Fourteen individuals with T1DM (age 35 ± 4 years; BMI 26.0 ± 1.4 kg/m
Indexed as
AdultAnimalsBlood GlucoseBrainDiabetes Mellitus, Type 1FemaleGlucoseGlycated HemoglobinHumansHyperglycemiaHypoglycemic AgentsMaleModels, TheoreticalRatsRats, Sprague-DawleyBlood GlucoseGlucoseGlycated HemoglobinHypoglycemic Agents
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.