Evidence map›Paper›PMID 30327357›Full record

ArticleDiabetes care2018

Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.

Surya N Mulukutla, Maria Acevedo-Calado, Christiane S Hampe, Massimo Pietropaolo, Ashok Balasubramanyam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Diabetic ketoacidosis.Nature reviews. Disease primers · 2020
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Surya N MulukutlaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-0447-0638
Maria Acevedo-CaladoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX.
Christiane S HampeDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA.
Massimo PietropaoloDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX massimo.pietropaolo@bcm.edu ashokb@bcm.edu.
Ashok BalasubramanyamDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX massimo.pietropaolo@bcm.edu ashokb@bcm.edu.ORCID 0000-0003-2093-5201
Baylor College of Medicine · USUniversity of Washington · US

Funding

IMPROVING PREDICTION OF IDDMR01DK053456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERMAN, MARK A, REDONDO, MARIA JOSE · 1999 to 2021
$9.5M
Arginine and Nitric Oxide Synthesis in the Pathogenesis of Ketosis-Prone DiabetesR01DK101411 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BALASUBRAMANYAM, ASHOK, JAHOOR, FAROOK · 2014 to 2018
$2.1M
NIDDK NIH HHS R01 DK053456NIDDK NIH HHS R01 DK101411
6 · The paper itself

Abstract

objectiveAutoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the intracellular domain of IA-2. Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA), >60% of adults lack three classic islet autoantibodies-IA-2, GAD65, and ZnT8 Abs-associated with type 1 diabetes. We aimed to determine whether apparently autoantibody-negative ("A-") KPD patients possess occult IA-2 Ab directed against full-length IA-2 (IA-2FL) or its extracellular domain (IA-2EC). RESEARCH DESIGN AND

methodsWe developed an assay that targets IA-2FL and IA-2EC and used it to analyze 288 subjects with A- KPD.

resultsTen A- KPD patients were positive for IA-2EC Ab (3.5%), and three were also positive for IA-2FL Ab (1.0%), similar to frequencies in type 1 and type 2 diabetes.

conclusionsMeasurement of IA-2FL Ab and IA-2EC Ab improves the accuracy of the Aβ classification of KPD patients.

Indexed as

AdolescentAdultAutoantibodiesBiomarkersChildCohort StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisDiagnosis, DifferentialFemaleHumansImmunoassayMaleMiddle AgedProtein DomainsAutoantibodiesBiomarkersICA512 autoantibodyPTPRN protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 8

Identifiers

PMID30327357
PMCPMC6245211
OpenAlexW2897167181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.