ArticleProceedings of the National Academy of Sciences of the United States of America2018
Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07604272 (Reversing InGuinal Hernia Trial), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reversing InGuinal Hernia Trial (RIGHT Trial): The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- A mechanistic exploration of IL-1β / p38 MAPK / MMP-2 pathway in inguinal hernia: evidence from clinical specimens and in vitro model.Surgical endoscopy · 2026Article
- Role of progesterone action in inguinal hernia formation via skeletal muscle fibrosis and atrophy.JCI insight · 2025Article
- Estrogen receptor-α ablation reverses muscle fibrosis and inguinal hernias.The Journal of clinical investigation · 2025Article
- Article
- Measurement of Knowledge and Practice of Saudi Population Towards Hernias and Its Risk Factors.Cureus · 2023Article
- Exploring the association between canine perineal hernia and neurological, orthopedic, and gastrointestinal diseases.Acta veterinaria Scandinavica · 2022Article
- Article
- miR-222 Is Involved in the Amelioration Effect of Genistein on Dexamethasone-Induced Skeletal Muscle Atrophy.Nutrients · 2022Article
- An estrogen-sensitive fibroblast population drives abdominal muscle fibrosis in an inguinal hernia mouse model.JCI insight · 2022Article
- Article
- Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Acute, Subchronic, and Chronic Complications of Radical Prostatectomy Versus Radiotherapy With Hormone Therapy in Older Adults With High-Risk Prostate Adenocarcinoma.Frontiers in oncology · 2022Article
- Safety of Inguinal Hernia Repair in the Elderly with Perioperative Continuation of Antithrombotic Therapy.Visceral medicine · 2021Article
- Comprehensive analysis reveals a six-gene signature and associated drugs in mimic inguinal hernia model.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Brain Aromatase and the Regulation of Sexual Activity in Male Mice.Endocrinology · 2020Article
- Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice.International journal of molecular sciences · 2020Article
- A network analysis revealed the essential and common downstream proteins related to inguinal hernia.PloS one · 2020Article
- Contribution of heparin to recovery of incarcerated intestine in a rat incarcerated hernia model.Hernia : the journal of hernias and abdominal wall surgery · 2019Article
- MicroRNA let-7 Downregulates Ligand-Independent Estrogen Receptor-mediated Male-Predominant Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Inguinal hernia develops primarily in elderly men, and more than one in four men will undergo inguinal hernia repair during their lifetime. However, the underlying mechanisms behind hernia formation remain unknown. It is known that testosterone and estradiol can regulate skeletal muscle mass. We herein demonstrate that the conversion of testosterone to estradiol by the aromatase enzyme in lower abdominal muscle (LAM) tissue causes intense fibrosis, leading to muscle atrophy and inguinal hernia; an aromatase inhibitor entirely prevents this phenotype. LAM tissue is uniquely sensitive to estradiol because it expresses very high levels of estrogen receptor-α. Estradiol acts via estrogen receptor-α in LAM fibroblasts to activate pathways for proliferation and fibrosis that replaces atrophied myocytes, resulting in hernia formation. This is accompanied by decreased serum testosterone and decreased expression of the androgen receptor target genes in LAM tissue. These findings provide a mechanism for LAM tissue fibrosis and atrophy and suggest potential roles of future nonsurgical and preventive approaches in a subset of elderly men with a predisposition for hernia development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.