Evidence map›Paper›PMID 30327343›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior.

Sukhee Cho, Allie K Muthukumar, Tobias Stork, Jaeda C Coutinho-Budd, Marc R Freeman

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. eLife · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. bioRxiv : the preprint server for biology · 2025
    Article
  6. Glial Regulation of Circuit Wiring, Firing, and Expiring in theCold Spring Harbor perspectives in biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Drosophila glia take shape to sculpt the nervous system.Current opinion in neurobiology · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. TheGenome research · 2021
    Article
  20. Neuromyelitis optica (NMO)-IgG-driven organelle reorganization in human iPSC-derived astrocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sukhee ChoDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605.
Allie K MuthukumarDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605.
Tobias StorkVollum Institute, Oregon Health and Sciences University, Portland, OR 97239.
Jaeda C Coutinho-BuddDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605.
Marc R FreemanVollum Institute, Oregon Health and Sciences University, Portland, OR 97239 freemmar@ohsu.edu.
University of Massachusetts Chan Medical School · USVollum Institute · US

Funding

The Draper signaling pathway in Drosophila glial immune functionsR01NS053538 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Marc R Freeman · 2006 to 2026
$5.3M
Astrocyte control of neural circuits and behaviorR37NS053538 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEMAN, MARC R · 2016 to 2022
$2.9M
Transmission Electron Microscope for Core EM FacilityS10RR027897 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2009 to 2009
$500k
NCRR NIH HHS S10 RR027897NINDS NIH HHS R01 NS053538NINDS NIH HHS R37 NS053538
6 · The paper itself

Abstract

Astrocytes are important regulators of neural circuit function and behavior in the healthy and diseased nervous system. We screened for molecules in

Indexed as

AnimalsAstrocytesBiological TransportDrosophilaExcitatory Amino Acid Transporter 1Focal AdhesionsGlutamatesNeuronsSeizuresExcitatory Amino Acid Transporter 1GlutamatesastrocyteDrosophilafocal adhesionsglutamate transportershyperexcitability

Identifiers

PMID30327343
PMCPMC6217442
OpenAlexW2896089133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.