ReviewEvidence-based mental health2018
Progress in diagnosis and treatment of bipolar disorder among children and adolescents: an international perspective.
Review in Evidence-based mental health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Evaluation of the arachidonic acid pathway in bipolar disorder: a systematic review.Molecular biology reports · 2020Pooled it
- Effects of accelerated intermittent θ burst stimulation on depressive episodes and cognitive function in adolescents with bipolar disorder.BMC psychiatry · 2025Trial
- Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.Journal of translational medicine · 2025Trial
- Revisiting the prevalence of bipolar disorder: implications of a broader spectrum model.Frontiers in psychiatry · 2026Review
- Differentiating Between Major Depressive Disorder and Bipolar Disorder.Advances in experimental medicine and biology · 2026Review
- Impact of childhood trauma on depressive symptoms in bipolar adolescents: the mediating effect of sleep disturbance.BMC psychiatry · 2025Article
- Machine learning-driven simplification of the hypomania checklist-32 for adolescent: a feature selection approach.International journal of bipolar disorders · 2024Article
- Neuromodulation Strategies in Lifelong Bipolar Disorder: A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2024Review
- Article
- Risk of Pediatric Bipolar Disorder After General Anesthesia in Infants and Toddlers: A Propensity Score-Matched Population-Based Cohort Study.Schizophrenia bulletin · 2024Article
- Establishment and validation a relapse prediction model for bipolar disorder.Frontiers in psychiatry · 2024Article
- Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2023Article
- What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence.Brain sciences · 2021Review
- Valproate for acute mania.The Cochrane database of systematic reviews · 2019Review
- Celebrating the achievements of evidence-based child and adolescent mental health … and looking ahead to its continuous growth.Evidence-based mental health · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder (BPD) is a potentially lifelong condition characterised by extreme changes in mood that may begin in childhood and cause substantial impairment. Over the past decades, BPD has been the focus of increased attention mainly due to controversies surrounding its prevalence, diagnosis and treatment in children and adolescents. This report addresses these controversies by reviewing the extant evidence base, providing clinicians with a summary of the literature on diagnosis, phenomenology and treatment of paediatric BPD. The debate regarding diagnosing children with BPD based on severe irritability and aggression is mostly resolved. The current data support utilising the diagnostic criteria based on episodic changes of mood polarity. Therefore, longitudinal course of illness should be explored in detail when diagnosing BPD. Given high rates of genetic predisposition for BPD, assessment of youth should focus on obtaining accurate family history of this condition. Additionally, there has been a substantial increase in randomised placebo-controlled clinical trials evaluating pharmacological agents for mood stabilisation in children and adolescents, which we summarise in this review. Despite significant progress being made in the field of paediatric BPD, more research is needed in the areas of phenomenology, pathophysiology, course and treatment of this condition in youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.