Evidence map›Paper›PMID 30327333›Full record

ArticleRNA (New York, N.Y.)2019

The role of RNA structure in translational regulation by L7Ae protein in archaea.

Lin Huang, Saira Ashraf, David M J Lilley

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Archaeal RNA processing and regulation: expanding the functional landscape.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lin HuangCancer Research UK Nucleic Acid Structure Research Group, The University of Dundee, Dundee DD1 5EH, United Kingdom.
Saira AshrafCancer Research UK Nucleic Acid Structure Research Group, The University of Dundee, Dundee DD1 5EH, United Kingdom.
David M J LilleyCancer Research UK Nucleic Acid Structure Research Group, The University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0001-6882-2818
University of Dundee · GB

Funding

Biotechnology and Biological Sciences Research Council B17092Biotechnology and Biological Sciences Research Council BB/E001777/1Cancer Research UK 11722Cancer Research UK 18604
6 · The paper itself

Abstract

A recent study has shown that archaeal L7Ae binds to a putative k-turn structure in the 5'-leader of the mRNA of its structural gene to regulate translation. To function as a regulator, the RNA should be unstructured in the absence of protein, but it should adopt a k-turn-containing stem-loop on binding L7Ae. Sequence analysis of UTR sequences indicates that their k-turn elements will be unable to fold in the absence of L7Ae, and we have demonstrated this experimentally in solution using FRET for the

Indexed as

5' Untranslated RegionsArchaeal ProteinsArchaeoglobus fulgidusBase SequenceBinding SitesCrystallography, X-RayModels, MolecularNucleic Acid ConformationProtein BindingProtein BiosynthesisProtein ConformationRibosomal ProteinsRNA, ArchaealRNA, MessengerRNA Stability5' Untranslated RegionsArchaeal ProteinsRibosomal ProteinsRNA, ArchaealRNA, Messengergene regulationkink-turnRNA structureX-ray crystallography

Identifiers

PMID30327333
PMCPMC6298567
OpenAlexW2895784977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.