Evidence map›Paper›PMID 30327183›Full record

ArticleResearch in social & administrative pharmacy : RSAP2019

Development and content validation of measures assessing adherence barriers and behaviors for use in clinical care.

R J Fredericksen, F M Yang, L E Gibbons, T C Edwards, S Brown, E Fitzsimmons, K Alperovitz-Bichell, M Godfrey, A Wang, A Church and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in social & administrative pharmacy : RSAP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

R J FredericksenUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA. Electronic address: rfrederi@uw.edu.
F M YangAugusta University, 1120 15th Street Augusta, GA, 30912, USA.
L E GibbonsUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA.
T C EdwardsUniversity of Washington, Quality of Life Group, Box 359455, Seattle, WA, 98195, USA.
S BrownUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA.
E FitzsimmonsUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA.
K Alperovitz-BichellChase Brexton Health Care, 5500 Knoll N Dr #370, Columbia, MD, 21045, USA.
M GodfreyBeaufort Jasper Hampton Comprehensive Health Services, 1520 Grays Highway, Ridgeland, SC, 29936, USA.
A WangChase Brexton Health Care, 5500 Knoll N Dr #370, Columbia, MD, 21045, USA.
A ChurchUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA.
C GutierrezFenway Community Health, 1340 Boylston Street, Boston, MA, 02215, USA.
E PaezUniversity of California-San Diego, The Owen Clinic, 4168 Front Street, San Diego, CA, 92103, USA.
L DantFenway Community Health, 1340 Boylston Street, Boston, MA, 02215, USA.
S LooFenway Community Health, 1340 Boylston Street, Boston, MA, 02215, USA.
M WalcottUniversity of Alabama-Birmingham, 1917 Clinic, Community Care Building, 908 South 20th Street, Birmingham, AL, 35294, USA.
M J MugaveroUniversity of Alabama-Birmingham, 1917 Clinic, Community Care Building, 908 South 20th Street, Birmingham, AL, 35294, USA.
K H MayerFenway Community Health, 1340 Boylston Street, Boston, MA, 02215, USA.
W C MathewsUniversity of California-San Diego, The Owen Clinic, 4168 Front Street, San Diego, CA, 92103, USA.
D L PatrickUniversity of Washington, Quality of Life Group, Box 359455, Seattle, WA, 98195, USA.
P K CraneUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA.
H M CraneUniversity of Washington, Center for AIDS Research, 325 Ninth Avenue, Box 359931, Seattle, WA, 98104, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Patient reported outcomes in routine clinical care of patients infected with HIVU01AR057954 · NIAMS · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., CRANE, PAUL K · 2009 to 2013
$7.8M
3/4 Alcohol Research Consortium in HIV - Epidemiological Research Arm (ARCH-ERA)U01AA020793 · NIAAA · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., LAU, BRYAN · 2011 to 2020
$5.8M
Training in Health Services Research for Vulnerable PopulationsT32HS022242 · AHRQ · BOSTON MEDICAL CENTER · PI LAROCHELLE, MARC · 2013 to 2024
$4.1M
AHRQ HHS T32 HS022242NIAAA NIH HHS U01 AA020793NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027767NIAID NIH HHS R24 AI067039NIAMS NIH HHS U01 AR057954
6 · The paper itself

Abstract

backgroundProviders are often unaware of poor adherence to prescribed medications for their patients with chronic diseases.

objectiveTo develop brief, computer-administered patient-reported measures in English and Spanish assessing adherence behaviors and barriers. Design, Participants, and Main Measures: Item pools were constructed from existing measures of medication adherence behaviors and barriers, which informed development of a patient concept elicitation interview guide to identify medication adherence behavior and barrier-related concepts. Two hundred six patients either living with HIV (PLWH) or without were interviewed. Interviews were coded, concepts matched to item pool content, and new items were developed for novel concepts. A provider/investigator team highlighted clinically relevant items. Cognitive interviews were conducted with patients on final candidate items (n = 37). The instruments were administered to 2081 PLWH. KEY

resultsBehavioral themes from concept elicitation interviews included routines incorporating time of day, placement, visual cues, and intentionality to miss or skip doses. Barrier themes included health-related (e.g. depressed mood, feeling ill), attitudes/beliefs (e.g., need for medication), access (e.g., cost/insurance problems), and circumstantial barriers (e.g., lack of privacy, disruption of daily routine). The final instruments included 6 behavior items, and 1 barrier item with up to 23 response options. PLWH endorsed a mean (SD) of 3.5 (1.1) behaviors. The 201 PLWH who missed ≥2 doses in the previous week endorsed a mean (SD) of 3.1 (2.5) barriers. The intraclass correlation coefficient (ICC) for the numbers of behaviors endorsed in 61 PLWH after 4-16 days was 0.54 and for the number of barriers for the 20 PLWH with ≥2 missed doses the ICC was 0.89, representing fair and excellent test-retest reliability.

conclusionMeasures of medication adherence behaviors and barriers were developed for use with patients living with chronic diseases focusing on clinical relevance, brevity, and content validity for use in clinical care.

Indexed as

Drug MonitoringAdultChronic DiseaseFemaleHIV InfectionsHumansMaleMiddle AgedSelf ReportMedication adherencePatient-reported outcomes

Identifiers

PMID30327183
PMCPMC7946330

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.