ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2018
Hepatitis E in Italy: 5 years of national epidemiological, virological and environmental surveillance, 2012 to 2016.
Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hepatitis E Virus in Water Environments: A Systematic Review and Meta-analysis.Food and environmental virology · 2022Pooled it
- Hepatitis E virus infection: considerations for immunologists and rheumatologists.Rheumatology international · 2026Review
- Genetic insights into hepatitis E virus through environmental surveillance in Europe.One health (Amsterdam, Netherlands) · 2026Review
- Statistical Relationship Between Wastewater Data and Case Notifications for COVID-19 Surveillance in the United States From 2020 to 2023: Bayesian Hierarchical Modeling Approach.JMIR public health and surveillance · 2025Article
- Article
- The first detection of SARS-CoV-2 RNA in the wastewater of Bucharest, Romania.Scientific reports · 2024Article
- Detection of Hepatitis E Virus in Game Meat (Wild Boar) Supply Chain in Umbria Region, Central Italy.Foods (Basel, Switzerland) · 2024Article
- Article
- Protocol for detection of pathogenic enteric RNA viruses by regular monitoring of environmental samples from wastewater treatment plants using droplet digital PCR.Science in One Health · 2024Article
- Seroprevalence of anti-HEV IgG in children: very early exposure in young children in a hyperendemic region.Frontiers in public health · 2023Article
- High Prevalence and Genetic Heterogeneity of Genotype 3 Hepatitis E Virus in Wild Boar in Umbria, Central Italy.Transboundary and emerging diseases · 2023Article
- Hepatitis E virus in pigs and the environment: An updated review of public health concerns.Narra J · 2022Review
- Prevalence and risk factors for hepatitis E virus infection in blood donors: a nationwide survey in Italy, 2017 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Article
- Quantitative Methods for the Prioritization of Foods Implicated in the Transmission of Hepatititis E to Humans in Italy.Foods (Basel, Switzerland) · 2021Article
- Monitoring Emergence of the SARS-CoV-2 B.1.1.7 Variant through the Spanish National SARS-CoV-2 Wastewater Surveillance System (VATar COVID-19).Environmental science & technology · 2021Article
- Differences in Incidence of Acute Viral Hepatitis between Foreigners and Autochthonous Population in Italy.International journal of environmental research and public health · 2021Article
- Hepatitis E Virus (HEV) Spread and Genetic Diversity in Game Animals in Northern Italy.Food and environmental virology · 2021Article
- Hepatitis E in Sub Saharan Africa - A significant emerging disease.One health (Amsterdam, Netherlands) · 2021Review
- Hepatitis E Virus Occurrence in Pigs Slaughtered in Italy.Animals : an open access journal from MDPI · 2021Article
- Whole Genome Sequencing Characterization of HEV3-Microorganisms · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing numbers of hepatitis E cases are being reported in several European countries, including Italy, but the burden of hepatitis E virus (HEV) infection is largely unknown in the latter. To gain a better understanding of HEV epidemiology at national level in Italy, we piloted a strengthened and integrated human (epidemiological and virological) and environmental HEV surveillance system between 2012 and 2016. Over the 5-year period, 169 confirmed hepatitis E cases were identified, with a national annual incidence of 0.72 cases per 1,000,000. Of 65 HEV-RNA positive samples of sufficient quality for molecular analysis, 66% were genotype HEV3, 32% HEV1 and 1% HEV4. The most frequent risk factor reported by all HEV3 infected cases, was the consumption of undercooked pork and sausage. For the environmental surveillance, 679 urban sewage samples were collected from 53 wastewater treatment plants and HEV-RNA was detected in 38/679 of the samples. Among these, 25 (66%) were genotype HEV3 and the remaining were HEV1. We demonstrate that autochthonous transmission and environmental circulation of genotype HEV3 is adding to travel-related HEV transmission in Italy. We recommend the 'One Health' approach to integrated surveillance, and to include HEV-related messages within health information campaigns focussing on food security.
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