Evidence map›Paper›PMID 30326968›Full record

Trial reportBMC cancer2018

A prospective clinical and biological database for pancreatic adenocarcinoma: the BACAP cohort.

Cindy Canivet, Sophie Gourgou-Bourgade, Bertrand Napoléon, Laurent Palazzo, Nicolas Flori, Pierre Guibert, Guillaume Piessen, Dominique Farges-Bancel, Jean-François Seitz, Eric Assenat and 9 more

Registry-linked trialOpen access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02818829 (Biological and Clinical Database for Pancreatic Adenocarcinoma), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02818829 active not recruitingnot on this map

Biological and Clinical Database for Pancreatic Adenocarcinoma

TypeobservationalSponsorUniversity Hospital, ToulouseRan2014 to 2029Enrolled1,700ConditionsPancreatic AdenocarcinomaArmsCollection of biological samples
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 1 country.

Cindy CanivetThe Department of Gastroenterology and Pancreatology, CHU - Rangueil and the University of Toulouse, 1 avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
Sophie Gourgou-BourgadeThe Biometrics Unit - CTD Inca, the Cancer Institute and the University of Montpellier, Montpellier, France.
Bertrand NapoléonThe Department of Gastroenterology, Jean Mermoz Hospital, Ramsay Générale de Santé, Lyon, France.
Laurent PalazzoThe Department of Endoscopy, Trocadéro Clinic, Paris, France.
Nicolas FloriThe Department of Oncology, the Cancer Institute and the University of Montpellier, Montpellier, France.
Pierre GuibertThe Department of Oncology, Leon Bérard Institute, Lyon, France.
Guillaume PiessenUniv. Lille, Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, F-59000, Lille, France.
Dominique Farges-BancelThe Department of Internal Medicine, Saint-Louis Hospital and Paris 7 Diderot University, Paris, France.
Jean-François SeitzThe Department of Oncology, CHU - La Timone and the University of Marseille, Marseille, France.
Eric AssenatThe Department of Oncology, CHU - ST-Eloi and the University of Montpellier, Montpellier, France.
Véronique VendrelyThe Department of Oncology and Radiotherapy, CHU - Haut-Levêque and the University of Bordeaux, Bordeaux, France.
Stéphanie TruantThe Department of Digestive Surgery and Transplantation, the CHU and the University of Lille, Lille, France.
Geoffroy VanbiervlietThe Department of Gastroenterology, CHU - L'Archet and the University of Nice, Nice, France.
Philippe BerthelémyThe Department of Gastroenterology, Pau Hospital, Pau, France.
Stéphane GarciaThe Department of Pathology, CHU - Nord and the University of Marseille, Marseille, France.
Anne Gomez-BrouchetThe Biobank, the Cancer Institute and the University of Toulouse, Toulouse, France.
Louis BuscailThe Department of Gastroenterology and Pancreatology, CHU - Rangueil and the University of Toulouse, 1 avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France.
Barbara BournetThe Department of Gastroenterology and Pancreatology, CHU - Rangueil and the University of Toulouse, 1 avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France. Bournet.b@chu-toulouse.fr.ORCID http://orcid.org/0000-0002-3679-9454
BACAP Consortium
Inserm · FRCentre Hospitalier Universitaire de Toulouse · FRUniversité de Lille · FRCentre de Recherche en Cancérologie de Toulouse · FRCentre Hospitalier De Pau · FRCentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier Universitaire de Nice · FRDélégation Paris 7 · FRHôpital Privé Jean Mermo · FRHôpital Saint-Louis · FRInstitut de Recherche en Cancérologie de Montpellier · FRInstitut universitaire du cancer de Toulouse Oncopole · FRUniversité de Bordeaux · FR

Funding

Institut National Du Cancer Grant INCA_6294
6 · The paper itself

Abstract

backgroundThe prognosis for pancreatic cancer remains poor despite diagnostic advances and treatments with new chemotherapeutic regimens. The five year survival rate remains below 3%. Consequently, there is an urgent need for new treatments to significantly improve the prognosis. In addition, there is a big gap in terms of the screening, early diagnosis and prevention of pancreatic cancer the incidence of which is increasing dramatically.

methodsDesign: the BACAP cohort is a prospective multicenter pancreatic cancer cohort (pancreatic ductal carcinoma) with clinical and multiple biological samples; Participating centers: 15 French academic and private hospitals; Study Population: any cytologically and/or histologically proven pancreatic carcinoma regardless of the stage (resectable, borderline, locally advanced or metastatic) or treatment (surgery, palliative chemotherapy, best supportive care). At least 1500 patients will be included. Clinical data collected include: disease presentation, epidemiological and social factors, baseline biology, radiology, endoscopic ultrasound, staging, pathology, treatments, follow-up (including biological and radiological), and survival. All these data are collected and stored through an e-observation system at a centralized data center. Biological samples and derived products (i.e. before any treatment): blood, saliva, endoscopic ultrasound-guided fine needle aspiration materials from the primary tumor, fine needle biopsy of metastases and surgically resected tissue. DNA and RNA are extracted from fine needle aspiration materials and are quantified and characterized for quality. Whole blood, plasma and serum are isolated from blood samples. Frozen tissues were specifically allocated to the cohort. All derived products and saliva are stored at - 80 °C. Main end-points: i) to centralize clinical data together with multiple biological samples that are harmonized in terms of sampling, the post sampling process and storage; ii) to identify new molecular markers for the diagnosis, prognosis and possibly the predictive response to pancreatic cancer surgery and or chemotherapy. DISCUSSION: The BACAP cohort is a unique prospective biological clinical database that provides the opportunity to identify correlations between the presence/expression of a broad panel of biomarkers (DNA, RNA, miRNA, proteins, etc.), epidemiological and social data, various clinical situations, various stages and the differentiation of the tumor, treatments and survival.

trial registrationClinicalTrials.gov Identifier: NCT02818829 . Registration date: June 30, 2016.

Indexed as

Carcinoma, Pancreatic DuctalDatabases as TopicPancreatic NeoplasmsAgedBiomarkers, TumorCohort StudiesFemaleFranceHumansMaleMiddle AgedPrognosisBiomarkers, TumorBiobankBiomarkersCohort studyDNAOutcomesPancreatic adenocarcinomaQuality controlRNA

Identifiers

PMID30326968
PMCPMC6191891
OpenAlexW2896059350

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.