ArticleVirology journal2018
Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand.
Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Seroprevalence of coxsackievirus A6 and enterovirus A71 infection in humans: a systematic review and meta-analysis.Archives of virology · 2023Pooled it
- Surveillance of enterovirus infection and genotypes/subgenotypes of enteroviruses in Dak Lak, Vietnam in 2022-2024.IJID regions · 2026Article
- Enterovirus 71 seropositivity among children and adolescents in Bangladesh.IJID regions · 2025Article
- Article
- Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines.Virology journal · 2025Article
- Emergence and circulation of enterovirus B species in infants in southern China: A multicenter retrospective analysis.Virulence · 2024Article
- Stability and infectivity of enteroviruses on dry surfaces: Potential for indirect transmission control.Biosafety and health · 2023Article
- Diversity of Human Enterovirus Co-Circulations in Five Kindergartens in Bangkok between July 2019 and January 2020.Viruses · 2023Article
- Article
- Seroprevalence of anti-SARS-CoV-2 antibodies in Thai adults during the first three epidemic waves.PloS one · 2022Article
- Evaluation of different platforms for the detection of anti-SARS coronavirus-2 antibodies, Thailand.BMC infectious diseases · 2021Article
- Seroprevalence of coxsackievirus A16 antibody among people of various age groups: a systematic review and meta-analysis.Archives of public health = Archives belges de sante publique · 2021Review
- First seroepidemiological investigation of human enterovirus 71 in Iran.Iranian journal of microbiology · 2021Article
- Response of Severe EV71-Infected Patients to Hyperimmune Plasma Treatment: A Pilot Study.Pathogens (Basel, Switzerland) · 2021Article
- Epidemiological Study of Influenza A, Influenza B, Enterovirus 71, and Coxsackievirus A16 Among Children in the Central Region of Zhejiang Province, China.Current microbiology · 2020Article
- Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications.Scientific reports · 2020Article
- Seroprevalence of EV-A71 neutralizing antibodies following the 2011 epidemic in HCMC, Vietnam.PLoS neglected tropical diseases · 2020Article
- Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHand, foot and mouth disease (HFMD) is endemic among population of young children in Thailand. The disease is mostly caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16).
methodsThis study conducted serosurveillance for neutralizing (NT) antibodies to EV71 subgenotypes B5 and C4a, and to CA16 subgenotypes B1a and B1b, in 579 subjects of various ages using a microneutralization assay in human rhabdomyosarcoma (RD) cells. These test viruses were the major circulating subgenotypes associated with HFMD in Thailand during the study period.
resultsWe found that the levels of seropositivity against all 4 study viruses were lowest in the age group of 6-11 months, i.e., 5.5% had antibody to both EV71 subgenotypes, while 14.5% and 16.4% had antibody to CA16 subgenotypes B1a and B1b, respectively. The percentages of subjects with antibodies to these 4 viruses gradually increased with age, but were still less than 50% in children younger than 3 years. These laboratory data were consistent with the epidemiological data collected by the Ministry of Public Health which showed repeatedly that the highest number of HFMD cases was in children aged 1 year. Analyses of amino acid sequences of the test viruses showed 97% identity between the two subgenotypes of EV71, and 99% between the two subgenotypes of CA16. Nevertheless, the levels of seropositivity and antibody titer against the two subgenotypes of EV71 and of CA16 were not significantly different.
conclusionsThis study clearly demonstrated NT antibody activity across EV71-B5 and EV71-C4a subgenotypes, and also across CA16-B1a and CA16-B1b subgenotypes. Moreover, there were no significant differences by gender in the seropositive rates and antibody levels to any of the 4 virus subgenotypes.
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