SynthesisRespiratory research2018
High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis.
Synthesis in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507425 (High Flow Nasal Cannula With Noninvasive Ventilation and Its Effect on High Risk Trauma Patients), which is not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High Flow Nasal Cannula With Noninvasive Ventilation and Its Effect on High Risk Trauma Patients
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Efficacy of preventive use of oxygen therapy after planned extubation in high-risk patients with extubation failure: A network meta-analysis of randomized controlled trials.Frontiers in medicine · 2022Pooled it
- Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis.Critical care (London, England) · 2021Pooled it
- High-flow nasal cannulae for respiratory support in adult intensive care patients.The Cochrane database of systematic reviews · 2021Pooled it
- Preventive use of respiratory support after scheduled extubation in critically ill medical patients-a network meta-analysis of randomized controlled trials.Critical care (London, England) · 2020Pooled it
- The Impact of High-Flow Nasal Cannula on the Outcome of Immunocompromised Patients with Acute Respiratory Failure: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- High-flow nasal cannulae for respiratory support in adult intensive care patients.The Cochrane database of systematic reviews · 2017Pooled it
- The effectiveness of high-flow nasal cannula therapy in comparison with continuous positive airway pressure therapy in patients with obstructive sleep apnea: an open-label randomized crossover trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Trial
- An Analysis of the Effect of Noninvasive Positive Pressure Ventilation on Patients with Respiratory Failure Complicated by Diabetes Mellitus.Disease markers · 2022Trial
- Noninvasive ventilation versus conventional oxygen therapy after extubation failure in high-risk patients in an intensive care unit: a pragmatic clinical trial.Revista Brasileira de terapia intensiva · 2021Trial
- Retrospective Propensity-Matched Comparison of Noninvasive Positive Pressure Ventilation Versus High-Flow Nasal Cannula on Reintubation Rates in Neurosurgical Intensive Care Patients.Neurocritical care · 2026Article
- Review
- Real-time prediction of HFNC treatment failure in acute hypoxemic respiratory failure using machine learning.Scientific reports · 2025Article
- Effect of high-flow nasal cannula therapy on mechanical ventilation duration in the pediatric intensive care unit.PloS one · 2024Article
- Standardised Critical Care Strategies Improve Outcomes Following Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in an Indian Peritoneal Malignancy Centre.Indian journal of surgical oncology · 2023Article
- Article
- To: The Respiratory Rate-Oxygenation Index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study.Critical care science · 2023Article
- Prediction Model of Extubation Outcomes in Critically Ill Patients: A Multicenter Prospective Cohort Study.Journal of clinical medicine · 2022Article
- High-flow nasal cannula: Evaluation of the perceptions of various performance aspects among Chinese clinical staff and establishment of a multidimensional clinical evaluation system.Frontiers in medicine · 2022Article
- The Respiratory Rate-Oxygenation Index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study.Revista Brasileira de terapia intensiva · 2022Observational
- Effectiveness and Harms of High-Flow Nasal Oxygen for Acute Respiratory Failure: An Evidence Report for a Clinical Guideline From the American College of Physicians.Annals of internal medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHigh-flow nasal cannula (HFNC) can be used as an initial support strategy for patients with acute respiratory failure (ARF) and after extubation. However, no clear evidence exists to support or oppose HFNC use in clinical practice. We summarized the effects of HFNC, compared to conventional oxygen therapy (COT) and noninvasive ventilation (NIV), on important outcomes including treatment failure and intubation/reintubation rates in adult patients with ARF and after extubation.
methodsWe searched 4 electronic databases (Pubmed, EMBASE, Scopus, and Web of Science) to identify randomized controlled trials (RCTs) comparing the effects of HFNC with either COT or NIV on rates of 1) treatment failure and 2) intubation/reintubation in adult critically ill patients.
resultsWe identified 18 RCTs (n = 4251 patients) in pooled analyses. As a primary mode of support, HFNC treatment reduced the risk of treatment failure [Odds Ratio (OR) 0.65; 95% confidence interval (CI) 0.43-0.98; p = 0.04; I
conclusionsHFNC was superior to COT in reducing treatment failure when used as a primary support strategy and in reducing rates of extubation failure and reintubation when used after extubation. In few trials, HFNC reduced intubation rate compared to NIV when used as initial support but demonstrated no beneficial effects after extubation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.