ArticleBMC plant biology2018
Activation of a gene network in durum wheat roots exposed to cadmium.
Article in BMC plant biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Advances in Molecular Mechanisms Underlying Cadmium Accumulation and Detoxification in Durum Wheat (International journal of molecular sciences · 2026Review
- Xylem Parenchyma Anatomy and Gene Expression Patterns Indicate Mechanisms of Cavitation Resistance inPlant-environment interactions (Hoboken, N.J.) · 2025Article
- Transcription factors involved in plant responses to cadmium-induced oxidative stress.Frontiers in plant science · 2024Review
- AlfalfaFrontiers in plant science · 2024Article
- A Survey of the Transcriptomic Resources in Durum Wheat: Stress Responses, Data Integration and Exploitation.Plants (Basel, Switzerland) · 2023Review
- Cadmium exposure is associated with increased transcript abundance of multiple heavy metal associated transporter genes in roots of hemp (Frontiers in plant science · 2023Article
- Characteristics of cadmium accumulation and tolerance in apple plants grown in different soils.Frontiers in plant science · 2023Article
- Comparative transcriptome analysis provides novel insights into molecular response of salt-tolerant and sensitive polyembryonic mango genotypes to salinity stress at seedling stage.Frontiers in plant science · 2023Article
- Signal Transduction in Cereal Plants Struggling with Environmental Stresses: From Perception to Response.Plants (Basel, Switzerland) · 2022Review
- Effects of Cadmium on Root Morpho-Physiology of Durum Wheat.Frontiers in plant science · 2022Article
- The ethylene-responsive transcription factor of durum wheat, TdSHN1, confers cadmium, copper, and zinc tolerance to yeast and transgenic tobacco plants.Protoplasma · 2022Article
- Lead contamination affects the primary productivity traits, biosynthesis of macromolecules and distribution of metal in durum wheat (Saudi journal of biological sciences · 2021Article
- Exogenous Glutathione Alleviates Cadmium Toxicity in Wheat by Influencing the Absorption and Translocation of Cadmium.Bulletin of environmental contamination and toxicology · 2021Article
- Molecular Responses to Cadmium Exposure in Two Contrasting Durum Wheat Genotypes.International journal of molecular sciences · 2021Article
- Breeding for low cadmium accumulation cereals.Journal of Zhejiang University. Science. B · 2020Review
- Cadmium Uptake by Wheat (Plants (Basel, Switzerland) · 2020Review
- A Comprehensive Transcriptome-Wide Identification and Screening of WRKY Gene Family Engaged in Abiotic Stress in Glycyrrhiza glabra.Scientific reports · 2020Article
- Article
- Combined Effect of Cadmium and Lead on Durum Wheat.International journal of molecular sciences · 2019Article
- The R2R3-MYB Transcription Factor MYB49 Regulates Cadmium Accumulation.Plant physiology · 2019Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAmong cereals, durum wheat (Triticum turgidum L. subsp. durum) accumulates cadmium (Cd) at higher concentration if grown in Cd-polluted soils. Since cadmium accumulation is a risk for human health, the international trade organizations have limited the acceptable concentration of Cd in edible crops. Therefore, durum wheat cultivars accumulating low cadmium in grains should be preferred by farmers and consumers. To identify the response of durum wheat to the presence of Cd, the transcriptomes of roots and shoots of Creso and Svevo cultivars were sequenced after a 50-day exposure to 0.5 μM Cd in hydroponic solution.
resultsNo phytotoxic effects or biomass reduction was observed in Creso and Svevo plants at this Cd concentration. Despite this null effect, cadmium was accumulated in root tissues, in shoots and in grains suggesting a good cadmium translocation rate among tissues. The mRNA sequencing revealed a general transcriptome rearrangement after Cd treatment and more than 7000 genes were found differentially expressed in root and shoot tissues. Among these, the up-regulated genes in roots showed a clear correlation with cadmium uptake and detoxification. In particular, about three hundred genes were commonly up-regulated in Creso and Svevo roots suggesting a well defined molecular strategy characterized by the transcriptomic activation of several transcription factors mainly belonging to bHLH and WRKY families. bHLHs are probably the activators of the strong up-regulation of three NAS genes, responsible for the synthesis of the phytosiderophore nicotianamine (NA). Moreover, we found the overall up-regulation of the methionine salvage pathway that is tightly connected with NA synthesis and supply the S-adenosyl methionine necessary for NA biosynthesis. Finally, several vacuolar NA chelating heavy metal transporters were vigorously activated.
conclusionsIn conclusion, the exposure of durum wheat to cadmium activates in roots a complex gene network involved in cadmium translocation and detoxification from heavy metals. These findings are confident with a role of nicotianamine and methionine salvage pathway in the accumulation of cadmium in durum wheat.
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