ArticleBMC infectious diseases2018
Oseltamivir in pregnancy and birth outcomes.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Management of Newborns Exposed to Maternal Influenza: A Scoping Review.Life (Basel, Switzerland) · 2026Review
- Paternal Valproate Use and Neurodevelopmental Disorder and Congenital Malformation Risk in Offspring.JAMA network open · 2025Observational
- A population-based cohort to evaluate drug safety during pregnancy (PREGVAL): rationale, design, and baseline characteristics.European journal of epidemiology · 2025Article
- Review
- Maternal Influenza and Offspring Neurodevelopment.Current issues in molecular biology · 2024Review
- The relationship between prior psychiatric diagnosis and brain cancer diagnosis in the U.S. military health system.Cancer causes & control : CCC · 2022Article
- [Internal medical emergencies in the pregnant patient : Peripartum sepsis, metabolic derailment, endocrinological emergencies and pulmonary edema].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022Article
- Mapping Outcomes and Registries Used in Current Danish Pharmacoepidemiological Research.Clinical epidemiology · 2022Review
- [Internal medical emergencies in the pregnant patient : Peripartum sepsis, metabolic derailment, endocrinological emergencies and pulmonary edema].Der Anaesthesist · 2021Article
- SARS-CoV-2 in the context of past coronaviruses epidemics: Consideration for prenatal care.Prenatal diagnosis · 2020Review
- Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019.American journal of obstetrics & gynecology MFM · 2020Review
- Congenital Malformations in Denmark: Considerations for the Use of Danish Health Care Registries.Clinical epidemiology · 2020Article
- Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report.Tropical medicine and infectious disease · 2019Article
- H1N1 Infection in Pregnancy; A Retrospective Study of Feto-Maternal Outcome and Impact of the Timing of Antiviral Therapy.Mediterranean journal of hematology and infectious diseases · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPrenatal exposure to influenza or fever is associated with risk of congenital malformations. Oseltamivir is used to treat influenza and to provide post-exposure prophylaxis. We examined the association between oseltamivir use during pregnancy and birth outcomes.
methodsThis was a nationwide registry-based prevalence study with individual level data linkage, in a setting of universal health care access. We included all recorded pregnancies in Denmark in 2002-2013, and used data from population registries to examine associations between dispensings for oseltamivir during pregnancy (first trimester, second/third trimester, none) and congenital malformations, foetal death, preterm birth, foetal growth, and low 5-min Apgar score. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using propensity score matching.
resultsThe study included 946,176 pregnancies. Of these, 449 had first-trimester exposure and 1449 had second/third-trimester exposure to oseltamivir. Adjusted ORs following first-trimester exposure were 0.94 (95% CI 0.49 to 1.83) for any major congenital malformation and 1.75 (95% CI 0.51 to 5.98) for congenital heart defects, based on 7 exposed cases. The association with congenital heart defects was present for etiologically implausible exposure periods and for known safe exposures. There was no evidence of an association between prenatal exposure to oseltamivir and any of the other birth outcomes assessed.
conclusionsThe study does not provide evidence of risk associated with oseltamivir treatment additional to that associated with influenza infection.
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