Evidence map›Paper›PMID 30326795›Full record

ArticleGlobal health action2018

Strengthening health technology assessment systems in the global south: a comparative analysis of the HTA journeys of China, India and South Africa.

Kim MacQuilkan, Peter Baker, Laura Downey, Francis Ruiz, Kalipso Chalkidou, Shankar Prinja, Kun Zhao, Thomas Wilkinson, Amanda Glassman, Karen Hofman

Open access · goldAbstract readComparative Study
In one paragraph

Article in Global health action, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
27.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  3. Regulatory and HTA framework for herbal medicines in Indonesia.Journal of pharmaceutical policy and practice · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Kim MacQuilkana Priority Cost Effective Lessons for System Strengthening South Africa (PRICELESS SA), Faculty of Health Sciences , School of Public Health, University of Witwatersrand , Johannesburg , South Africa.ORCID 0000-0002-9785-6934
Peter Bakerb Global Health and Development Group , Institute of Global Health Innovation, Imperial College London , London , UK.ORCID 0000-0001-9028-9976
Laura Downeyb Global Health and Development Group , Institute of Global Health Innovation, Imperial College London , London , UK.ORCID 0000-0002-9563-7113
Francis Ruizb Global Health and Development Group , Institute of Global Health Innovation, Imperial College London , London , UK.
Kalipso Chalkidoub Global Health and Development Group , Institute of Global Health Innovation, Imperial College London , London , UK.
Shankar Prinjac School of Public Health , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Kun Zhaod Division of Health Technology Assessment and Policy Evaluation , China National Health Development Research Center (CHNHDR), Ministry of Health , Beijing , China.
Thomas Wilkinsona Priority Cost Effective Lessons for System Strengthening South Africa (PRICELESS SA), Faculty of Health Sciences , School of Public Health, University of Witwatersrand , Johannesburg , South Africa.
Amanda Glassmane Center for Global Development , Washington , DC , USA.
Karen Hofmana Priority Cost Effective Lessons for System Strengthening South Africa (PRICELESS SA), Faculty of Health Sciences , School of Public Health, University of Witwatersrand , Johannesburg , South Africa.
Imperial College London · GBUniversity of the Witwatersrand · ZACenter for Global Development · USChina National Health Development Research Center · CNPost Graduate Institute of Medical Education and Research · IN

Funding

Medical Research Council MR/R015600/1
6 · The paper itself

Abstract

backgroundResource allocation in health is universally challenging, but especially so in resource-constrained contexts in the Global South. Pursuing a strategy of evidence-based decision-making and using tools such as Health Technology Assessment (HTA), can help address issues relating to both affordability and equity when allocating resources. Three BRICS and Global South countries, China, India and South Africa have committed to strengthening HTA capacity and developing their domestic HTA systems, with the goal of getting evidence translated into policy. Through assessing and comparing the HTA journey of each country it may be possible to identify common problems and shareable insights.

objectivesThis collaborative paper aimed to share knowledge on strengthening HTA systems to enable enhanced evidence-based decision-making in the Global South by: Identifying common barriers and enablers in three BRICS countries in the Global South; and Exploring how South-South collaboration can strengthen HTA capacity and utilisation for better healthcare decision-making.

methodsA descriptive and explorative comparative analysis was conducted comprising a Within-Case analysis to produce a narrative of the HTA journey in each country and an Across-Case analysis to explore both knowledge that could be shared and any potential knowledge gaps.

resultsAnalyses revealed that China, India and South Africa share many barriers to strengthening and developing HTA systems such as: (1) Minimal HTA expertise; (2) Weak health data infrastructure; (3) Rising healthcare costs; (4) Fragmented healthcare systems; and (5) Significant growth in non-communicable diseases. Stakeholder engagement and institutionalisation of HTA were identified as two conducive factors for strengthening HTA systems.

conclusionChina, India and South Africa have all committed to establishing robust HTA systems to inform evidence-based priority setting and have experienced similar challenges. Engagement among countries of the Global South can provide a supportive platform to share knowledge that is more applicable and pragmatic.

Indexed as

ChinaDelivery of Health CareHumansIndiaResource AllocationSouth AfricaTechnology Assessment, BiomedicalCapacity buildingHTALMICspriority-settingsouth-south collaboration

Identifiers

PMID30326795
PMCPMC6197020
OpenAlexW2896028587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.