ArticleClinical and experimental otorhinolaryngology2019
Decellularization of Trachea With Combined Techniques for Tissue-Engineered Trachea Transplantation.
Article in Clinical and experimental otorhinolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Rapid and Efficient Combined Decellularization with Physical, Chemical and Enzymatic Treatment for Production of Bovine-Derived Meniscal Implant to Replace Damaged Meniscus.Tissue engineering and regenerative medicine · 2026Article
- Advances in Decellularization of Fish Wastes for Extracellular Matrix Extraction in Sustainable Tissue Engineering and Regenerative Medicine.Bioengineering (Basel, Switzerland) · 2026Review
- Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.Frontiers in cell and developmental biology · 2026Review
- In situ vascularization and epithelialization of segmental bioengineered trachea based on marrow-derived stem/progenitor cells.Materials today. Bio · 2025Article
- Tissue-Engineered Tracheal Reconstruction.Biomimetics (Basel, Switzerland) · 2025Review
- Organic and Synthetic Substitutes in Tracheal Reconstruction: A Scoping Review (2015-2025).Bioengineering (Basel, Switzerland) · 2025Review
- From Cartilage to Matrix: Protocols for the Decellularization of Porcine Auricular Cartilage.Bioengineering (Basel, Switzerland) · 2025Article
- Decellularization techniques: unveiling the blueprint for tracheal tissue engineering.Frontiers in bioengineering and biotechnology · 2025Review
- Decellularization of various tissues and organs through chemical methods.Tissue & cell · 2024Review
- An overview of the production of tissue extracellular matrix and decellularization process.Cell and tissue banking · 2024Review
- Current Strategies for Tracheal Decellularization: A Systematic Review.International journal of biomaterials · 2024Review
- Synergistic Effects of SDS and HInternational journal of biomaterials · 2024Article
- Analysis of cognitive framework and biomedical translation of tissue engineering in otolaryngology.Scientific reports · 2023Article
- Article
- Intravital microscopy datasets examining key nephron segments of transplanted decellularized kidneys.Scientific data · 2022Article
- Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects.The Laryngoscope · 2022Article
- Article
- 3D bioprinting of multi-layered segments of a vessel-like structure with ECM and novel derived bioink.Frontiers in bioengineering and biotechnology · 2022Article
- Hydrogel modification of 3D printing hybrid tracheal scaffold to construct an orthotopic transplantation.American journal of translational research · 2022Article
- Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal.Bioactive materials · 2021Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectivesThe purpose of this study is to shorten the decellularization time of trachea by using combination of physical, chemical, and enzymatic techniques.
methodsApproximately 3.5-cm-long tracheal segments from 42 New Zealand rabbits (3.5±0.5 kg) were separated into seven groups according to decellularization protocols. After decellularization, cellular regions, matrix and strength and endurance of the scaffold were followed up.
resultsDNA content in all groups was measured under 50 ng/mg and there was no significant difference for the glycosaminoglycan content between group 3 (lyophilization+deoxycholic acid+de-oxyribonuclease method) and control group (P=0.46). None of the decellularized groups was different than the normal trachea in tensile stress values (P>0.05). Glucose consumption and lactic acid levels measured from supernatants of all decellularized groups were close to group with cells only (76 mg/dL and 53 mg/L).
conclusionUsing combination methods may reduce exposure to chemicals, prevent the excessive influence of the matrix, and shorten the decellularization time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.