Evidence map›Paper›PMID 30326249›Full record

ArticleNeuroscience research2019

Angiopoietin-1/Tie2 signaling pathway contributes to the therapeutic effect of thymosin β4 on diabetic peripheral neuropathy.

Lei Wang, Michael Chopp, Alexandra Szalad, XueRong Lu, Mei Lu, Talan Zhang, Zheng Gang Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lei WangDepartment of Neurology, Henry Ford Hospital, USA. Electronic address: leiwang@neuro.hfh.edu.
Michael ChoppDepartment of Neurology, Henry Ford Hospital, USA; Department of Physics, Oakland University, Rochester, MI 48309, USA.
Alexandra SzaladDepartment of Neurology, Henry Ford Hospital, USA.
XueRong LuDepartment of Neurology, Henry Ford Hospital, USA.
Mei LuDepartment of Biostatistics and Research Epidemiology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
Talan ZhangDepartment of Biostatistics and Research Epidemiology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
Zheng Gang ZhangDepartment of Neurology, Henry Ford Hospital, USA.
Henry Ford Hospital · US

Funding

Thymosin Beta4 Promotes the Recovery of Peripheral neuropathy in Type II DiabeticR01DK097519 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WANG, LEI · 2013 to 2016
$1.3M
PDE5 is a Therapeutic Target for Peripheral Neuropathy in Diabetic MiceR01NS075084 · NINDS · HENRY FORD HEALTH SYSTEM · PI WANG, LEI · 2012 to 2015
$1.3M
NIDDK NIH HHS R01 DK097519NINDS NIH HHS R01 NS075084
6 · The paper itself

Abstract

Angiopoietin-1 (Ang1) and its receptor Tie2 regulate vascular function. Our previous study demonstrated that thymosin beta 4 (Tβ4) ameliorates neurological function of diabetic peripheral neuropathy. Mechanisms underlying the therapeutic effect of Tβ4 on diabetic peripheral neuropathy have not been fully investigated. The present in vivo study investigated whether the Ang1/Tie2 signaling pathway is involved in Tβ4-improved neurovascular remodeling in diabetic peripheral neuropathy. Diabetic BKS. Cg-m+/+Lepr

Indexed as

Angiopoietin-1AnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDiabetic NeuropathiesMiceMice, TransgenicNerve FibersReceptor, TIE-2Sciatic NerveSignal TransductionThymosinThymosin beta(4)Angiopoietin-1Angpt1 protein, mouseBlood GlucoseReceptor, TIE-2Tek protein, mouseThymosinThymosin beta(4)Anti-Tie2Diabetic peripheral neuropathyMouseThymosin β4

Identifiers

PMID30326249
PMCPMC6462258
OpenAlexW2897739152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.