ArticleJournal of neuroscience methods2019
An open-source automated surgical instrument for microendoscope implantation.
Article in Journal of neuroscience methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods.Current protocols · 2025Article
- Individual differences in prelimbic neural representation of food and cocaine seeking.Cell reports · 2024Article
- Aberrant neural activity in prefrontal pyramidal neurons lacking TDP-43 precedes neuron loss.Progress in neurobiology · 2022Article
- Striatal direct pathway neurons play leading roles in accelerating rotarod motor skill learning.iScience · 2022Article
- Detailed mapping of behavior reveals the formation of prelimbic neural ensembles across operant learning.Neuron · 2022Article
- Stereotaxic Viral Injection and Gradient-Index Lens Implantation for Deep Brain In Vivo Calcium Imaging.Journal of visualized experiments : JoVE · 2021Article
- Through the looking glass: A review of cranial window technology for optical access to the brain.Journal of neuroscience methods · 2021Review
- Fluorescence microendoscopy for in vivo deep-brain imaging of neuronal circuits.Journal of neuroscience methods · 2021Article
- Circuit Investigation of Social Interaction and Substance Use Disorder Using Miniscopes.Frontiers in neural circuits · 2021Review
- Assembly and operation of an open-source, computer numerical controlled (CNC) robot for performing cranial microsurgical procedures.Nature protocols · 2020Article
- Circuit Mechanisms of Neurodegenerative Diseases: A New Frontier With Miniature Fluorescence Microscopy.Frontiers in neuroscience · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGradient index (GRIN) lenses can be used to image deep brain regions otherwise inaccessible via standard optical imaging methods. Brain tissue aspiration before GRIN lens implantation is a widely adopted approach. However, typical brain tissue aspiration methods still rely on a handheld vacuum needle, which is subject to human error and low reproducibility. Therefore, a high-precision automated surgical instrument for brain tissue aspiration is desirable. NEW
methodWe developed a robotic surgical instrument that utilizes robotic control of a needle connected to a vacuum pump to aspirate brain tissue. The system was based on a commercial stereotaxic instrument, and the additional parts can be purchased off-the-shelf or Computer Numerical Control (CNC) machined. A MATLAB-based user-friendly graphical user interface (GUI) was developed to control the instrument.
resultsWe demonstrated the GRIN lens implantation procedure in the dorsal striatum utilizing our proposed surgical instrument and confirmed the surgical results by microscope after the implantation. COMPARE WITH EXISTING METHOD(S): Compared to the traditional handheld method, the automatic tissue aspiration can be performed by interacting with GUI. The instrument was designed specifically for microendoscope implantation, but it can also be easily adapted for robotic craniotomy. This robotic surgical instrument can minimize human error, reduce training time, and greatly increase surgical precision.
conclusionsOur robotic surgical instrument is an ideal solution for brain tissue aspiration prior to GRIN lens implantation. It will be useful for neuroscientists performing in vivo deep brain imaging using miniature microscope or two-photon microscope combined with microendoscopes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.