Evidence map›Paper›PMID 30326201›Full record

ReviewBiochemical pharmacology2019

Differences between acute and chronic stress granules, and how these differences may impact function in human disease.

Lucas C Reineke, Joel R Neilson

Open access · hybridAbstract readReview
In one paragraph

Review in Biochemical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 107 citations in OpenAlex.

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  17. MNature communications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lucas C ReinekeDepartment of Molecular Physiology and Biophysics, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. Electronic address: lcreinek@bcm.edu.
Joel R NeilsonDepartment of Molecular Physiology and Biophysics, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · US

Funding

Translational control of EMT by the CELF1 RNA Binding ProteinR01CA190467 · NCI · BAYLOR COLLEGE OF MEDICINE · PI NEILSON, JOEL R · 2015 to 2021
$1.9M
Prospective Identification of Translational Regulators in EMTR21CA185769 · NCI · BAYLOR COLLEGE OF MEDICINE · PI NEILSON, JOEL R · 2015 to 2016
$379k
NCI NIH HHS R01 CA190467NCI NIH HHS R21 CA185769
6 · The paper itself

Abstract

Stress granules are macromolecular aggregates of mRNA and proteins assembling in response to stresses that promote the repression of protein synthesis. Most of the work characterizing stress granules has been done under acute stress conditions or during viral infection. Comparatively less work has been done to understand stress granule assembly during chronic stress, specifically regarding the composition and function of stress granules in this alternative context. Here, we describe key aspects of stress granule biology under acute stress, and how these stress granule hallmarks differ in the context of chronic stress conditions. We will provide perspective for future work aimed at further uncovering the form and function of both acute and chronic stress granules and discuss aspects of stress granule biology that have the potential to be exploited in human disease.

Indexed as

AnimalsHumansOxidative StressProtein BiosynthesisRNA, MessengerStress, PhysiologicalRNA, Messenger

Identifiers

PMID30326201
PMCPMC6421087
OpenAlexW2898030745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.