Evidence map›Paper›PMID 30326172›Full record

ArticleEuropean journal of neurology2019

Coffee, tea, and caffeine intake and amyotrophic lateral sclerosis mortality in a pooled analysis of eight prospective cohort studies.

J Petimar, É O'Reilly, H-O Adami, P A van den Brandt, J Buring, D R English, D M Freedman, G G Giles, N Håkansson, T Kurth and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.International journal of environmental research and public health · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

J PetimarHarvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-3025-5931
É O'ReillyHarvard T.H. Chan School of Public Health, Boston, MA, USA.
H-O AdamiKarolinska Institutet, Stockholm, Sweden.
P A van den BrandtCaphri School, Maastricht University, Maastricht, The Netherlands.
J BuringDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
D R EnglishCancer Council Victoria, Melbourne, VIC, Australia.
D M FreedmanNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
G G GilesCancer Council Victoria, Melbourne, VIC, Australia.
N HåkanssonKarolinska Institutet, Stockholm, Sweden.
T KurthInstitute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
S C LarssonKarolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0118-0341
K RobienMilken Institute School of Public Health, The George Washington University, Washington, DC, USA.
L J SchoutenCaphri School, Maastricht University, Maastricht, The Netherlands.
E WeiderpassKarolinska Institutet, Stockholm, Sweden.
A WolkKarolinska Institutet, Stockholm, Sweden.
S A Smith-WarnerHarvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

CVD Epidemiology Training Program in Behavior, the Environment and Global HealthT32HL098048 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Goodarz Danaei, ERIC B RIMM · 2009 to 2026
$6.9M
Pooling of Prospective Studies of Diet, Lifestyle and ALSR01NS072494 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI O'REILLY, EILIS · 2011 to 2013
$524k
NHLBI NIH HHS T32 HL098048NINDS NIH HHS R01 NS072494NINDS NIH HHS R01-NS072494-01A1
6 · The paper itself

Abstract

background and purposeCaffeine is associated with a lower risk of some neurological diseases, but few prospective studies have investigated caffeine intake and risk of amyotrophic lateral sclerosis (ALS) mortality. We therefore determined associations between coffee, tea and caffeine intake, and risk of ALS mortality.

methodsWe conducted pooled analyses of eight international, prospective cohort studies, including 351 565 individuals (120 688 men and 230 877 women). We assessed coffee, tea and caffeine intake using validated food-frequency questionnaires administered at baseline. We used Cox regression to estimate study- and sex-specific risk ratios and 95% confidence intervals (CI) for ALS mortality, which were then pooled using a random-effects model. We conducted analyses using cohort-specific tertiles, absolute common cut-points and continuous measures of all exposures.

resultsDuring follow-up, 545 ALS deaths were documented. We did not observe statistically significant associations between coffee, tea or caffeine intake and risk of ALS mortality. The pooled multivariable risk ratio (MVRR) for ≥3 cups per day vs. >0 to <1 cup per day was 1.04 (95% CI, 0.74-1.47) for coffee and 1.17 (95% CI, 0.77-1.79) for tea. The pooled MVRR comparing the highest with the lowest tertile of caffeine intake (mg/day) was 0.99 (95% CI, 0.80-1.23). No statistically significant results were observed when exposures were modeled as tertiles or continuously.

conclusionsOur results do not support associations between coffee, tea or total caffeine intake and risk of ALS mortality.

Indexed as

CaffeineCoffeeRisk AssessmentTeaAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisFemaleHumansMaleMiddle AgedProspective StudiesCaffeineCoffeeTeaamyotrophic lateral sclerosiscaffeinecoffeepooled analysesprospective cohort studiestea

Identifiers

PMID30326172
PMCPMC6365186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.