ArticleJAMA ophthalmology2018
Incidence and Early Course of Retinopathy of Prematurity: Secondary Analysis of the Postnatal Growth and Retinopathy of Prematurity (G-ROP) Study.
Article in JAMA ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Gestational Age-Specific Prevalence of Retinopathy of Prematurity in Very Preterm Infants: An Exploratory Meta-Analysis.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- Non-pharmacological pain relief interventions in preterm neonates undergoing screening for retinopathy of prematurity: a systematic review.BMJ open ophthalmology · 2023Pooled it
- Retinal vascular development in an immature retina at 33-34 weeks postmenstrual age predicts retinopathy of prematurity.Scientific reports · 2020Trial
- Validation of the DIGIROP 2.0 Models in predicting the risk of treatment-requiring retinopathy of prematurity in a Taiwanese cohort.Eye (London, England) · 2026Article
- Within- and between-country variation in gestational age thresholds for retinopathy of prematurity screening in Latin America.Maternal health, neonatology and perinatology · 2026Article
- Exposure to Type 1 and Type 2 Maternal Diabetes is Associated with Stage 3-5 Retinopathy of Prematurity.Ophthalmology science · 2026Article
- Retinopathy of Prematurity: Historical Evolution of Clinical Management and Medico-Legal Evaluation in Japan.Healthcare (Basel, Switzerland) · 2026Review
- Retinopathy of Prematurity (ROP): Are We There Yet?Medicina (Kaunas, Lithuania) · 2026Review
- Comparison of Ventilation Support During Laser Treatment of Retinopathy of Prematurity.Children (Basel, Switzerland) · 2026Article
- Polyunsaturated Fatty Acid Balance Modulates Microglial State in a Murine Model of Oxygen-Induced Neovascularization.Nutrients · 2026Article
- Research on the construction of an AI diagnostic model for plus disease of retinopathy of prematurity based on cross-center fusion datasets.Frontiers in pediatrics · 2026Article
- Machine Learning Risk Prediction for Treated Retinopathy of Prematurity in Infants.Neonatology · 2026Article
- Short-Term Efficacy of Two-Step Treatment of Retinopathy of Prematurity in a Japanese Cohort: Anti-VEGF Therapy Followed by Routine Laser Photocoagulation.Journal of clinical medicine · 2025Article
- Polyunsaturated fatty acid balance modulates microglial state in a murine model of oxygen-induced neovascularization.Research square · 2025Article
- Prognostic nutritional index in retinopathy of prematurity: a potential indicator of disease severity?International ophthalmology · 2025Article
- Screening for retinopathy of prematurity in South Africa: are those developing severe ROP screened on time? Data from a prospective register.BMJ open ophthalmology · 2025Article
- The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity.Diagnostics (Basel, Switzerland) · 2025Article
- Incidence, risk factors and evolving treatment of severe retinopathy of prematurity in China: a retrospective multicenter cohort study in 70 neonatal intensive care units.Frontiers in medicine · 2025Article
- An international survey on retinopathy of prematurity practice patterns during the COVID-19 pandemic and lessons for future management.International ophthalmology · 2024Article
- Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants.JAMA network open · 2024Article
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8 authors at 5 institutions in 1 country.
Funding
Abstract
Importance: The current guidelines for retinopathy of prematurity (ROP) detection programs in the United States include a range of birth weights (BWs) and gestational ages and likely require examinations of many premature infants who are at low risk for developing serious retinopathy. Objective: To determine the incidence, onset, and early course of ROP in what to our knowledge is the largest cohort to date that is representative of infants who are undergoing ROP screening. Design, Setting, and Participants: This secondary analysis of data from the Postnatal Growth and Retinopathy of Prematurity (G-ROP) retrospective cohort study was conducted in 29 hospitals in the United States and Canada between January 2006 and December 2011 and included 7483 infants who underwent serial ROP examinations. Main Outcomes and Measures: Most severe ROP in either eye, classified as no ROP, mild ROP, type 2 ROP, or type 1 ROP (per Early Treatment for ROP Study criteria). Onset at postmenstrual age for zone I disease and stage of ROP, plus disease, and treatment. Results: This study included 7483 infants with a mean (SD) BW of 1099 (259) g and a mean (SD) gestational age of 28 (3) weeks who underwent ROP examinations. Of these, 3224 infants (43.1%) developed ROP, 459 (6.1%) developed type 1 and 472 (6.3%) type 2 ROP, 514 (6.9%) underwent treatment in 1 or both eyes, and 147 (2%) had zone I disease. Additionally, 98.1% of type 1 or 2 ROP cases occurred in infants with a BW of less than 1251 g. Only about half of the eyes (49.4%) were vascularized into zone III by 37 weeks postmenstrual age. Conclusions and Relevance: These findings add to our knowledge of ROP screening as they include all eligible infants, not just high-risk infants as in previous studies. More than 40% of at-risk premature infants develop some stage of ROP, and most retinopathy regresses without treatment. However, approximately 12.5% develop severe ROP, which occurs almost exclusively among infants with a BW of less than 1251 g.
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