Evidence map›Paper›PMID 30325942›Full record

Trial reportPloS one2018

2-octyl cyanoacrylate sealing of the pancreatic remnant after distal pancreatectomy - A prospective pilot study.

Felix J Hüttner, Pascal Probst, Hannes G Kenngott, Phillip Knebel, Thilo Hackert, Alexis Ulrich, Markus W Büchler, Markus K Diener

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. The using of sealants in pancreatic surgery: A Systematic Review.Annals of medicine and surgery (2012) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Felix J HüttnerDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-2299-964X
Pascal ProbstDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Hannes G KenngottDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Phillip KnebelDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Thilo HackertDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Alexis UlrichDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Markus W BüchlerDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Markus K DienerDepartment of General-, Visceral- and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DEGerman Society of Surgery · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative pancreatic fistula (POPF) remains a frequent problem especially after distal pancreatectomy. The application of 2-octyl cyanoacrylate showed promising results in the reduction of POPF after pancreatoduodenectomy prompting an expansion of this technique to distal pancreatectomy. Thus, the objective of the current study was to assess safety, feasibility and preliminary efficacy of an intraoperative 2-octyl cyanoacrylate application after distal pancreatectomy.

methodsBetween April 2015 and June 2016 adult patients scheduled for elective distal pancreatectomy were considered eligible for the study. It was planned to include a total of 35 patients. After distal pancreatectomy with hand-sewn closure of the pancreatic remnant, a 2-octyl cyanoacrylate surgical glue was applied to the cut surface of the pancreas. Patients were followed up for three months with main focus on safety in terms of (serious) adverse events. Further endpoints included POPF, other pancreas-specific and surgical complications.

results15 patients were included in the study because the manufacturer stopped production and distribution of the investigational device thereafter. There was a total of ten serious adverse events but no device-related events and no mortality. The serious adverse events depicted a typical safety profile after distal pancreatectomy. POPF occurred in five cases (33.3%), delayed gastric emptying and post-pancreatectomy haemorrhage in two cases respectively (13.3%).

conclusionsApplication of 2-octyl cyanoacrylate to the pancreatic remnant after distal pancreatectomy seems feasible and safe. The planned evaluation of preliminary efficacy was not possible due to the inadvertent early termination and subsequent small sample size of the study. Novel techniques for prevention and therapy of POPF should be evaluated in future trials.

Indexed as

AdultAgedAged, 80 and overCyanoacrylatesFemaleHumansMaleMiddle AgedPancreatectomyPancreatic FistulaPilot ProjectsPostoperative ComplicationsProspective StudiesTissue AdhesivesCyanoacrylatesoctyl 2-cyanoacrylateTissue Adhesives

Identifiers

PMID30325942
PMCPMC6191135
OpenAlexW2897242353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.